FocusUNet: Pioneering dual attention with gated U-Net for colonoscopic polyp segmentation.

The detection and excision of colorectal polyps, precursors to colorectal cancer (CRC), can improve survival rates by up to 90%. Automated polyp segmentation in colonoscopy images expedites diagnosis and aids in the precise identification of adenomatous polyps, thus mitigating the burden of manual image analysis. This study introduces FocusUNet, an innovative bi-level nested U-structure integrated with a dual-attention mechanism. The model integrates Focus Gate (FG) modules for spatial and channel-wise attention and Residual U-blocks (RSU) with multi-scale receptive fields for capturing diverse contextual information. Comprehensive evaluations on five benchmark datasets - Kvasir-SEG, CVC-ClinicDB, CVC-ColonDB, ETISLarib, and EndoScene - demonstrate Dice score improvements of 3.14% to 43.59% over state-of-the-art models, with an 85% success rate in cross-dataset validations, significantly surpassing prior competing models with sub-5% success rates. The model combines high segmentation accuracy with computational efficiency, featuring 46.64 million parameters, 78.09 GFLOPs, and 39.02 GMacs, making it suitable for real-time applications. Enhanced with Explainable AI techniques, FocusUNet provides clear insights into its decision-making process, improving interpretability. This combination of high performance, efficiency, and transparency positions FocusUNet as a powerful, scalable solution for automated polyp segmentation in clinical practice, advancing medical image analysis and computer-aided diagnosis.