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[用活土拉菌疫苗免疫对大鼠各种肿瘤株生长的影响]

[Effect of immunization with live tularemia vaccine on the growth of various tumor strains in rats].

作者信息

Zil'fian V N, Kumkumadzhian V A, Nersesian A K, Fichidzhian B S

出版信息

Vopr Onkol. 1985;31(11):66-70.

PMID:4072086
Abstract

The paper deals with a study of the effect of a single challenge with living tularemia vaccine on the growth of such transplantable tumors as Zajdela's hepatoma, Pliss' lymphosarcoma, Walker's carcinosarcoma, Schwetz' erythromyelosis and sarcoma 45 in Wistar rats. Immunization was followed by a significant (37.2-86%) inhibition of the rate of growth of the said tumors. Ascites was detected in half the vaccinated animals of Zajdela's hepatoma series, this being matched by 100% in controls.

摘要

本文研究了用活土拉菌疫苗单次激发对Wistar大鼠体内可移植性肿瘤(如扎伊德拉斯肝癌、普利斯淋巴肉瘤、沃克癌肉瘤、施韦茨红白血病和肉瘤45)生长的影响。免疫后,上述肿瘤的生长速度受到显著抑制(37.2 - 86%)。在扎伊德拉斯肝癌系列的半数接种动物中检测到腹水,而对照组的这一比例为100%。

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