Kashio Makiko
Department of Cell Physiology, Kumamoto University, Kumamoto, Japan.
Physiol Rep. 2025 Jan;13(1):e70164. doi: 10.14814/phy2.70164.
Transient receptor potential (TRP) channels with temperature sensitivities (thermo-TRPs) are involved in various physiological processes. Thermo-TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic/behavioral thermoregulatory responses to maintain body temperature in mammals. Moreover, most thermo-TRPs are functionally expressed in cells and tissues where the temperature is maintained at a constant core body temperature. To perform physiological functions, the activity of each thermo-TRP channel must be regulated by endogenous mechanisms at body temperature. Dysregulation of this process can lead to various diseases. This review highlights the endogenous factors regulating thermo-TRP activity and physiological functions at constant core body temperature.
具有温度敏感性的瞬时受体电位（TRP）通道（热TRP通道）参与多种生理过程。在外周感觉神经元中检测温度变化的热TRP通道在温度感知中具有不可或缺的功能，引发对有害温度的防御行为，并驱动自主/行为性体温调节反应以维持哺乳动物的体温。此外，大多数热TRP通道在温度维持于恒定核心体温的细胞和组织中功能性表达。为了执行生理功能，每个热TRP通道的活性必须在体温下通过内源性机制进行调节。这一过程的失调可导致各种疾病。本综述重点介绍了在恒定核心体温下调节热TRP活性和生理功能的内源性因素。
