Prediction of Composite Clinical Outcomes for Childhood Neuroblastoma Using Multi-Omics Data and Machine Learning.

Neuroblastoma is a common malignant tumor in childhood that seriously endangers the health and lives of children, making it essential to find effective prognostic markers to accurately predict their clinical outcomes. The development of high-throughput technology in the biomedical field has made it possible to obtain multi-omics data, whose integration can compensate for missing or unreliable information in a single data source. In this study, we integrated clinical data and two omics data, i.e., gene expression and DNA methylation data, to study the prognosis of neuroblastoma. Since the features in omics data are redundant, it is crucial to conduct feature selection on them. We proposed a two-step feature selection (TSFS) method to quickly and accurately select the optimal features, where the first step aims at selecting candidate features and the second step is to remove redundant features among them using our proposed maximal association coefficient (MAC). Our goal is to predict composite clinical outcomes for neuroblastoma patients, i.e., their survival time and vital status at the last follow-up, which was validated to be two inter-correlated tasks. We conducted a series of experiments and evaluated the experimental results using accuracy and AUC (area under the ROC curve) evaluation metrics, which indicated that by the combination of the integration of the three types of data, our proposed TSFS method and a multi-task learning method can synergistically improve the reliability and accuracy of the prediction models.