Roth D, Oron U
Exp Cell Biol. 1985;53(2):107-14. doi: 10.1159/000163302.
The sequential cytological events of the regeneration process, after partial excision of the gastrocnemius muscle in the rat, were followed by light and electron microscopy. During the first 2 days after injury leukocytes and macrophages infiltrate into the traumatized area. Myogenic regeneration is then characterized by mainly two repair mechanisms. Mononucleated cells, that populate the excised area, most probably fuse together to give rise to newly formed multinucleated myotubes that further develop to striated myofibers. Another mechanism involves the repair of injured muscle fibers by the possible fusion of mononucleated cells with their necrotic cut ends. Consequently, by addition of nuclei and new muscular material, sarcoplasmic outgrowths from the injured fibers are formed. It is concluded that mainly two repair mechanisms are involved in the regeneration process following partial excision of a muscle: addition of new muscle fibers in a process similar to that of embryonic myogenesis and also meristic growth from the injured fibers.
通过光学显微镜和电子显微镜观察，对大鼠腓肠肌部分切除后再生过程中的一系列细胞学事件进行了跟踪研究。在损伤后的头两天，白细胞和巨噬细胞浸润到创伤区域。肌源性再生主要有两种修复机制。填充切除区域的单核细胞很可能融合在一起，形成新形成的多核肌管，进而发育为横纹肌纤维。另一种机制涉及单核细胞与其坏死的断端可能融合，从而修复受损的肌纤维。因此，通过增加细胞核和新的肌肉物质，受损纤维形成肌浆突出。得出的结论是，肌肉部分切除后的再生过程主要涉及两种修复机制：在类似于胚胎肌发生的过程中添加新的肌纤维，以及受损纤维的分节生长。
