van den Berg B, van Blankenstein M
Digestion. 1985;31(1):1-8. doi: 10.1159/000199170.
A double-blind controlled trial was conducted in which the efficacy of cimetidine in a dosage of 20 mg/kg/24 h in preventing upper gastrointestinal hemorrhage was tested in 34 critically ill patients on assisted ventilation. In 28 patients, 14 on cimetidine and 14 on placebo, gastric pH measurements and blood loss measured by 51Cr-labelled erythrocytes could be analyzed. Although cimetidine produced a markedly lower number of days with a gastric pH below 3.5 (17.4% vs. 72.2%) 5 patients on cimetidine bled as against 1 on placebo. These results do not suggest that cimetidine was effective in preventing stress-induced upper gastrointestinal bleeding.
进行了一项双盲对照试验，在34例接受辅助通气的危重症患者中测试了剂量为20mg/kg/24h的西咪替丁预防上消化道出血的疗效。在28例患者中，14例接受西咪替丁治疗，14例接受安慰剂治疗，可以分析胃pH值测量结果以及用51Cr标记红细胞测量的失血量。尽管西咪替丁使胃pH值低于3.5的天数明显减少（17.4%对72.2%），但接受西咪替丁治疗的患者中有5例出血，而接受安慰剂治疗的患者中只有1例出血。这些结果并不表明西咪替丁在预防应激性上消化道出血方面有效。
