人绒毛膜促性腺激素对淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应的抑制作用。
Inhibitory effect of human chorionic gonadotrophin on lymphocyte blastogenic response to mitogen, antigen and allogeneic cells.
作者信息
Han T
出版信息
Clin Exp Immunol. 1974 Dec;18(4):529-35.
Abstract
inhibitory effect of human chorionic gonadotrophin on human lymphocyte blastogenic response to phytohaemagglutinin, Varidase or allogeneic cells without cytotoxicity is presented. The effect of this hormone is reversible and dose-related. A greater inhibition of lymphocyte response is observed when the cells are pre-incubated with human chorionic gonadotrophin 24 hr before the addition of stimulant. Its inhibitory effect gradually decreases with time when the hormone is added to cultures, 1–3 days after the addition of phytohaemagglutinin. These data support the hypothesis that human chorionic gonadotrophin and possibly other placental hormones might have prevented the maternal lymphocytes from recognizing the foetus as a foreign tissue, resulting in a state of successful pregnancy.
摘要
本文介绍了人绒毛膜促性腺激素对人淋巴细胞对植物血凝素、链激酶或同种异体细胞的增殖反应的抑制作用，且无细胞毒性。该激素的作用是可逆的且与剂量相关。当细胞在添加刺激物前24小时与人绒毛膜促性腺激素预孵育时，观察到对淋巴细胞反应的抑制作用更强。当在添加植物血凝素1 - 3天后将该激素添加到培养物中时，其抑制作用会随时间逐渐降低。这些数据支持这样的假说，即人绒毛膜促性腺激素以及可能的其他胎盘激素可能阻止了母体淋巴细胞将胎儿识别为外来组织，从而导致成功妊娠的状态。
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