Quah Alison Mei Fern, Ng Marcus Jia Ming, Zhang Li, Chan Yam Meng, Neo Shufen, Mak Malcolm, Hong Qiantai, Tan Glenn, Pan Ying, Yong Enming
Vascular Surgery Unit, Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore.
Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Int Wound J. 2025 Jan;22(1):e70127. doi: 10.1111/iwj.70127.
Diabetic foot wounds (DFW) are notoriously difficult to treat owing to poor vascularity, delayed healing and higher rates of infection. Human-derived acellular dermal matrices (ADM) have been used in DFW treatment, utilizing a matrix scaffold for new tissue generation. We investigate the efficacy of a micronized injectable human-derived ADM in the treatment of DFW. We retrospectively recruited 13 patients with diabetic foot wounds. Wounds were adequately debrided, and a micronized injectable ADM was applied. Wound sizes were recorded prior to treatment, at 2 and 4 weeks post-treatment. The mean defect of wounds treated was 19.21 cm. Our results showed a statistically significant reduction in wound size of 45% and 59% at 2 and 4 weeks post-treatment, respectively (p < 0.01). ADM was also effective in infected DFW as 84% of our wounds had positive tissue cultures at the time of application. Micronized injectable ADM has proven to be an effective treatment for DFW. Advantages include a ready-to-use injectable, single-stage treatment, minimal pain, mouldable matrix to fit any wound shape, allows for outpatient treatment and simple wound dressings.
糖尿病足伤口（DFW）由于血管状况不佳、愈合延迟和感染率较高，治疗起来 notoriously difficult。人源脱细胞真皮基质（ADM）已被用于DFW治疗，利用基质支架促进新组织生成。我们研究了一种微粉化可注射人源ADM治疗DFW的疗效。我们回顾性招募了13例糖尿病足伤口患者。对伤口进行充分清创，然后应用微粉化可注射ADM。在治疗前、治疗后2周和4周记录伤口大小。接受治疗的伤口平均缺损面积为19.21平方厘米。我们的结果显示，治疗后2周和4周伤口大小分别有45%和59%的统计学显著减小（p < 0.01）。ADM对感染性DFW也有效，因为我们84%的伤口在应用时组织培养呈阳性。微粉化可注射ADM已被证明是治疗DFW的有效方法。其优点包括即用型可注射、单阶段治疗、疼痛极小、可塑形基质适合任何伤口形状、允许门诊治疗以及简单的伤口敷料。
