Bogojevska Doksevska Milena, Todorova Teodora, Popovska Danica, Velkovski Vilijam, Angelovska Tamara, Foteva Marta, Kunovska Slavica Kostadinova, Kocev Smiljana Bundovska, Rebok Katerina, Samardziski Milan
University Clinic for Orthopedic Diseases, 1000 Skopje, North Macedonia.
Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 1000 Skopje, Republic of North Macedonia.
J Surg Case Rep. 2025 Jan 9;2025(1):rjae826. doi: 10.1093/jscr/rjae826. eCollection 2025 Jan.
Extraskeletal osteosarcoma (ESOS) represents a rare soft tissue entity, accounting for ⁓1% of all soft tissue malignancies. It is generally considered to have an even worse prognosis than bone osteosarcoma, therefore detailed investigations and proper treatment are required. ESOSs arising in the subcutaneous tissue are even rarer than the ones positioned in deep tissues, and they are considered to have far better outcomes. We present a case of a 49-year-old patient diagnosed with subcutaneous ESOS and Paget disease of the bone, which is not typical for the patient's age, considering that Paget disease of the bone tends to affect a population above 50 years. The coexistence of these two entities in a single patient and all their features make this case unique, and to the best of our knowledge, this is the first case reported.
骨外骨肉瘤（ESOS）是一种罕见的软组织肿瘤，约占所有软组织恶性肿瘤的1%。一般认为其预后比骨肉瘤更差，因此需要进行详细的检查和适当的治疗。发生于皮下组织的ESOS比深部组织的更为罕见，且被认为预后要好得多。我们报告一例49岁患者，诊断为皮下ESOS和骨佩吉特病，考虑到骨佩吉特病往往影响50岁以上人群，该病例在患者这个年龄并不典型。这两种疾病在同一患者体内共存及其所有特征使得该病例具有独特性，据我们所知，这是首例报道的病例。
