McBride J T
J Appl Physiol (1985). 1985 Mar;58(3):1010-4. doi: 10.1152/jappl.1985.58.3.1010.
To investigate the participation of the conducting airways in compensatory growth following partial lung resection, bronchial casts of six ferrets having undergone right-sided pneumonectomy at 8 wk of age were compared with those of five sham-operated control animals. At maturity, the left lungs of the postpneumonectomy animals were 65% larger than those of the controls. Central airway cross-sectional areas at 10 specific locations in each cast were 12% larger in the postpneumonectomy animals compared with controls. To characterize the size of more peripheral airways, the size and number of the terminal bronchioles subtended by each airway in each left lower lobe cast were identified so that the fraction of the lobe served by that airway could be estimated. The characteristic cross-sectional areas of airway serving 0.7, 2.2, and 9.5% of the left lower lobe in postpneumonectomy animals were 18, 13, and 13% larger than those of controls, but this difference was statistically significant only at the two more peripheral levels. Although airway areas were larger in postpneumonectomy animals, the ratio of airway cross-sectional area to the 0.67 power of lung volume was 20-26% smaller in operated than in control animals at each of the four levels. Following pneumonectomy in the weanling ferret, central and peripheral conducting airways increase in cross-sectional area to similar degrees, but this airway growth is less than the compensatory increase in lung volume.
为了研究部分肺切除术后传导气道在代偿性生长中的作用，将6只8周龄接受右侧肺切除术的雪貂的支气管铸型与5只假手术对照动物的支气管铸型进行比较。成熟时，肺切除术后动物的左肺比对照组大65%。与对照组相比，肺切除术后动物每个铸型中10个特定位置的中央气道横截面积大12%。为了描述更外周气道的大小，确定了每个左下叶铸型中每个气道所对应的终末细支气管的大小和数量，以便估计该气道所服务的肺叶部分。肺切除术后动物中服务于左下叶0.7%、2.2%和9.5%的气道的特征性横截面积分别比对照组大18%、13%和13%，但这种差异仅在两个更外周的水平上具有统计学意义。尽管肺切除术后动物的气道面积较大，但在四个水平中的每一个水平上，手术动物的气道横截面积与肺体积的0.67次幂之比都比对照动物小20 - 26%。在断奶期雪貂进行肺切除术后，中央和外周传导气道的横截面积以相似的程度增加，但这种气道生长小于肺体积的代偿性增加。
