Chen Hung-Lin, Hu Po-Yuan, Chen Chang-Shan, Lin Wei-Han, Hsu Daniel K, Liu Fu-Tong, Meng Tzu-Ching
Institute of Biomedical Sciences, Academia Sinica, Taipei City, Taiwan.
Institute of Biological Chemistry, Academia Sinica, Taipei City, Taiwan.
Microbiol Spectr. 2025 Feb 4;13(2):e0259924. doi: 10.1128/spectrum.02599-24. Epub 2025 Jan 13.
Colon cancer development may be initiated by multiple factors, including chronic inflammation, genetic disposition, and gut dysbiosis. The loss of beneficial bacteria and increased abundance of detrimental microbes exacerbates disease progression. () is a human gut microbe, and its colon colonization is enhanced by a seaweed-supplemented diet. We found that mice orally administered with and fed a diet containing 1% seaweed developed a unique gut microbial composition. By linear discriminant analysis effect size analysis, we found that colonization increased the abundance of and reduced the abundance of sp. and sp. We also showed that colonization of suppressed the colon tumor development induced by azoxymethane/dextran sulfate sodium in specific-pathogen-free mice, coinciding with a reduced abundance of sp., sp., and sp. Moreover, colonization in gnotobiotic mice resulted in enhanced production of selected metabolites, including propionic, taurocholic, cholic, alpha-, and beta-muricholic, as well as ursodeoxycholic acids. Importantly, some of these metabolites show anti-inflammatory and tumor-suppressive effects. We conclude that is able to restructure the gut microbial community and produce beneficial metabolites, leading to inhibition of colitis-associated colon cancer development.IMPORTANCEThis work delves into the pivotal role of gut microbiota in suppressing the progression of colitis-associated colon cancer. By investigating the impact of that can be colonized in mouse gut by feeding the animal with seaweed diet, we unveil a novel mechanism through which this beneficial bacterium reshapes the gut microbial community and produces metabolites with anti-inflammatory and tumor-suppressive properties. Such findings underscore the potential of harnessing specific microbes, like shown in this study, to modulate the gut ecosystem and mitigate the risk of colitis-associated colon cancer.
结肠癌的发生可能由多种因素引发，包括慢性炎症、遗传易感性和肠道菌群失调。有益菌的丧失和有害微生物数量的增加会加剧疾病进展。（某菌名）是一种人类肠道微生物，补充海藻的饮食可增强其在结肠的定殖。我们发现，口服（某菌名）并喂食含1%海藻饮食的小鼠形成了独特的肠道微生物组成。通过线性判别分析效应大小分析，我们发现（某菌名）定殖增加了（某有益菌名）的丰度，降低了（某有害菌名1）菌属和（某有害菌名2）菌属的丰度。我们还表明，（某菌名）定殖抑制了无特定病原体小鼠中由氧化偶氮甲烷/葡聚糖硫酸钠诱导的结肠肿瘤发展，同时伴随着（某有害菌名1）菌属、（某有害菌名2）菌属和（某有害菌名3）菌属丰度的降低。此外，（某菌名）在无菌小鼠中的定殖导致了选定代谢产物产量的增加，包括丙酸、牛磺胆酸、胆酸、α-和β-鼠胆酸以及熊去氧胆酸。重要的是，其中一些代谢产物具有抗炎和肿瘤抑制作用。我们得出结论，（某菌名）能够重构肠道微生物群落并产生有益代谢产物，从而抑制结肠炎相关结肠癌的发展。重要性这项工作深入探讨了肠道微生物群在抑制结肠炎相关结肠癌进展中的关键作用。通过研究通过给动物喂食海藻饮食可在小鼠肠道定殖的（某菌名）的影响，我们揭示了一种新机制，即这种有益细菌通过该机制重塑肠道微生物群落并产生具有抗炎和肿瘤抑制特性的代谢产物。这些发现强调了利用特定微生物（如本研究中所示的（某菌名））来调节肠道生态系统并降低结肠炎相关结肠癌风险的潜力。
