Safiri Saeid, Shamekh Ali, Hassanzadeh Kamaleddin, Fazlollahi Asra, Sullman Mark J M, Raeisi Mortaza, Kolahi Ali-Asghar
Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sci Rep. 2025 Jan 13;15(1):1853. doi: 10.1038/s41598-024-83840-3.
Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer. These metrics were reported as counts and age-standardised rates, each accompanied by 95% uncertainty intervals. In 2021, the age-standardised incidence of prostate cancer in the region was 27.4 per 100,000 population, representing a 125.1% increase from 1990. The age-standardised mortality rate was 10.1, and the age-standardised DALY rate was 173.6, neither of which showed significant increases since 1990. Qatar recorded the highest age-standardised DALY rate in 2021, while Algeria had the lowest. The largest number of incident cases, deaths, and DALYs in 2021 were found in the 65-69, 80-84, and 70-74 age groups, respectively. Additionally, from 1990 to 2021, the burden of prostate cancer largely increased with the socio-demographic index (SDI) at the regional level. The burden of prostate cancer in the MENA region rose markedly between 1990 and 2021. Further studies into the underlying causes of this increasing incidence are essential to devise effective strategies for the early detection and prevention of the disease.
前列腺癌是全球影响男性的最常见恶性肿瘤之一。本研究旨在记录1990年至2021年期间中东和北非（MENA）地区及其21个国家因前列腺癌导致的发病率、死亡人数和伤残调整生命年（DALYs）。我们分析了《2021年全球疾病负担》研究中可公开获取的数据，以呈现与前列腺癌相关的发病率、死亡人数和伤残调整生命年（DALYs）的研究结果。这些指标以计数和年龄标准化率报告，每个指标都伴有95%的不确定区间。2021年，该地区前列腺癌的年龄标准化发病率为每10万人27.4例，比1990年增长了125.1%。年龄标准化死亡率为10.1，年龄标准化DALY率为173.6，自1990年以来均未显示出显著增长。卡塔尔在2021年的年龄标准化DALY率最高，而阿尔及利亚最低。2021年，新增病例、死亡人数和DALYs数量最多的分别是65 - 69岁、80 - 84岁和70 - 74岁年龄组。此外，从1990年到2021年，前列腺癌的负担在区域层面上随着社会人口指数（SDI）的升高而大幅增加。1990年至2021年期间，中东和北非地区前列腺癌的负担显著上升。进一步研究这种发病率上升的潜在原因对于制定有效的早期检测和预防该疾病的策略至关重要。
