Guedes Laerte Jônatas Leray, Tavares Victória Brioso, Carneiro Saul Rassy, Neves Laura Maria Tomazi
Federal University of Pará (UFPA), R. Augusto Corrêa, 01 - Guamá, Belém, Pará, 66075-110, Brazil.
BMC Cancer. 2025 Jan 13;25(1):74. doi: 10.1186/s12885-024-13099-4.
Prescribing physical exercise as part of the clinical treatment of cancer patients has become an important strategy in the therapeutic arsenal available in the main health centers specialized in neoplastic diseases, but there is still uncertainty regarding the role of regular physical activity in modifying oxidative stress markers and antioxidants, as high levels of oxidative stress can lead to the development of carcinogens. Therefore, we assessed the effect of physical activity versus absence of physical activity on markers of oxidative stress and antioxidants in cancer patients.
We looked for randomized controlled trials that included adult with any type of cancer performing some physical activity and compared them to a control group of cancer patients with no physical activity. The outcomes of interest collected were markers of oxidative stress and antioxidants. Six databases were used for the search (EMBASE, The Cochrane Library (CENTRAL), US National Library of Medicine (PubMed), Physiotherapy Evidence Database (PEDro), Cumulative Index of Nursing and Allied Health (CINAHL) and SPORTDiscus via EBSCO) until January 31st, 2024.
In the end, 7 randomized controlled clinical trials were included, totaling 573 participants. It was possible to conduct a meta-analysis with demonstrated that physical activity potentially increases the antioxidant marker Trolox, Taoc, Gpx, (SMD = 1.23, CI: 0.13 to 2.34). However, these findings were classified as having very low to moderate GRADE evidence.
Cancer patients who participated in physical activity programs may have exhibited an increased concentration of antioxidants. Although the overall quality of the evidence in the studies was very low, these findings represent an important field of research that should be guided by studies with more participants and homogeneous methods of analysis of oxidant stress and antioxidant markers.
PROSPERO CRD42021257815.
将体育锻炼作为癌症患者临床治疗的一部分，已成为主要肿瘤疾病专科健康中心可用治疗手段中的一项重要策略，但关于规律体育活动在改变氧化应激标志物和抗氧化剂方面的作用仍存在不确定性，因为高水平的氧化应激会导致致癌物的产生。因此，我们评估了体育活动与缺乏体育活动对癌症患者氧化应激标志物和抗氧化剂的影响。
我们检索了随机对照试验，这些试验纳入了患有任何类型癌症且进行了一些体育活动的成年人，并将他们与不进行体育活动的癌症患者对照组进行比较。收集的相关结果是氧化应激和抗氧化剂的标志物。截至2024年1月31日，使用了六个数据库进行检索（EMBASE、Cochrane图书馆（CENTRAL）、美国国立医学图书馆（PubMed）、物理治疗证据数据库（PEDro）、护理及相关健康累积索引（CINAHL）和通过EBSCO的SPORTDiscus）。
最终，纳入了7项随机对照临床试验，共有573名参与者。可以进行荟萃分析，结果表明体育活动可能会增加抗氧化剂标志物Trolox、Taoc、Gpx（标准化均数差=1.23，可信区间：0.13至2.34）。然而，这些发现被归类为具有极低至中等质量的GRADE证据。
参加体育活动项目的癌症患者可能表现出抗氧化剂浓度增加。尽管研究中的证据总体质量非常低，但这些发现代表了一个重要的研究领域，应该通过有更多参与者以及采用氧化应激和抗氧化剂标志物分析方法更统一的研究来加以指导。
PROSPERO CRD42021257815
