Bimerew Melaku, Getie Addisu, Gebreegziabher Araya Freweyni, Dessalegn Nigatu, Wondmieneh Adam, Ayalneh Manay
Department of Pediatric and Child Health Nursing, Injibara University, Injibara, Ethiopia
Department of Nursing, Debre Markos University, Debre Markos, Ethiopia.
BMJ Open. 2024 Dec 22;14(12):e084003. doi: 10.1136/bmjopen-2024-084003.
To assess the pooled in-hospital mortality among neonates with necrotising enterocolitis (NEC) in Ethiopia.
This was a systematic review and meta-analysis reported based on the Preferred Reporting Items for Systematic Review and Meta-analysis guideline.
African Journals Online, PubMed/Medline, Google Scholar, Cochrane Library and repositories of Ethiopian Universities.
Published and unpublished articles that had reported the in-hospital mortality among neonates with NEC in Ethiopia were included, whereas, articles with no abstracts and/or inaccessible full texts, citations, reviews, commentaries editorials, conference abstracts, anonymous reports and articles reported in non-English language were excluded.
Articles that passed the eligibility criteria were assessed for their quality using the quality appraisal criteria for prevalence studies. Data extraction and cleaning were done by using the Microsoft Excel work sheet, and data were analysed by STATA V.11.0 using the random effects model at 95% CI. Test of heterogeneity, publication bias, sensitivity analysis, subgroup analysis and meta-regression were performed.
A total of 12 articles involving 588 neonates were included. The pooled in-hospital mortality among neonates with NEC in Ethiopia was found to be 70.0% (95% CI=60.0% to 80.0%; I=87.5%). There was significant difference in mortality by study population as the in-hospital mortality among neonates with NEC was 83.0% (95% CI=76.0% to 89.0%; I=42.8%; five studies) in preterm neonates and 73.0% (95% CI=60.0% to 86.0%; I=66.3%; four studies) in low birthweight neonates (p<0.001).
The in-hospital mortality of neonates with NEC in Ethiopia was found to be high in which 7 out of 10 neonates diagnosed with NEC ends with death. Therefore, the currently available NEC prevention strategies should be evaluated for individual units and introduced where possible.
评估埃塞俄比亚坏死性小肠结肠炎（NEC）新生儿的合并住院死亡率。
这是一项基于系统评价和Meta分析的首选报告项目指南进行报告的系统评价和Meta分析。
非洲在线期刊、PubMed/Medline、谷歌学术、Cochrane图书馆以及埃塞俄比亚各大学的知识库。
纳入已发表和未发表的报告埃塞俄比亚NEC新生儿住院死亡率的文章，而排除无摘要和/或无法获取全文的文章、引文、综述、评论社论、会议摘要、匿名报告以及非英文报告的文章。
使用患病率研究的质量评估标准对通过纳入标准的文章进行质量评估。使用Microsoft Excel工作表进行数据提取和清理，并使用STATA V.11.0在95%置信区间下采用随机效应模型进行数据分析。进行异质性检验、发表偏倚检验、敏感性分析、亚组分析和Meta回归分析。
共纳入12篇涉及588例新生儿的文章。发现埃塞俄比亚NEC新生儿的合并住院死亡率为70.0%（95%置信区间=60.0%至80.0%；I²=87.5%）。按研究人群划分，死亡率存在显著差异，因为NEC新生儿的住院死亡率在早产儿中为83.0%（95%置信区间=76.0%至89.0%；I²=42.8%；5项研究），在低出生体重儿中为73.0%（95%置信区间=60.0%至86.0%；I²=66.3%；4项研究）（p<0.001）。
发现埃塞俄比亚NEC新生儿的住院死亡率很高，每10例被诊断为NEC的新生儿中有7例最终死亡。因此，应针对各个单位评估当前可用的NEC预防策略，并在可能的情况下加以引入。
