Ji Wentao, Deng Yu, Zheng Min, Zhang Xiaoting, Lu Jun, Liu Jinhai, Li Bo, Bo Lulong
Naval Medical University, Shanghai, China.
Naval Medical University, Shanghai, China
BMJ Open. 2024 Dec 20;14(12):e092868. doi: 10.1136/bmjopen-2024-092868.
Hypoxaemia is a frequent complication associated with endoscopy conducted under intravenous sedation, highlighting the need for effective and practical interventions. This systematic review aims to evaluate the effectiveness of nasal mask oxygenation in reducing the incidence of hypoxaemia during endoscopy under intravenous sedation compared with the conventional oxygen supply.
This study strictly adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol guidelines. PubMed, Embase, Cochrane Library, Web of Science and China National Knowledge Infrastructure databases will be electronically searched from their inception to May 2024 to identify randomised controlled trials comparing a nasal mask with conventional oxygen supply for endoscopy under intravenous sedation. The study selection, data extraction and quality assessment processes will be conducted independently by two reviewers. The risk of bias in the included studies will be assessed using the Cochrane Risk of Bias Tool for Randomized Trials, and the strength of evidence will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation guidelines. The meta-analysis will be performed using STATA V.16.0, with effect sizes calculated using the standardised mean difference and 95% CI. Heterogeneity will be assessed using Cochran's Q statistics, and inconsistency will be measured using I statistics. Potential sources of bias will also be evaluated.
The data used for this systematic review will be exclusively extracted from published studies. Additional ethical approval and informed consent are not required. This systematic review will be published in a peer-reviewed journal and will be presented at conferences and congresses.
CRD42024545231.
低氧血症是静脉镇静下进行内镜检查时常见的并发症，这凸显了采取有效且实用干预措施的必要性。本系统评价旨在评估与传统氧气供应相比，鼻罩给氧在降低静脉镇静下内镜检查期间低氧血症发生率方面的有效性。
本研究严格遵循系统评价与Meta分析方案的首选报告项目指南。将对PubMed、Embase、Cochrane图书馆、科学网和中国知网数据库进行电子检索，检索时间从建库至2024年5月，以识别比较鼻罩与传统氧气供应用于静脉镇静下内镜检查的随机对照试验。研究选择、数据提取和质量评估过程将由两名 reviewers 独立进行。将使用Cochrane随机试验偏倚风险工具评估纳入研究的偏倚风险，并使用推荐分级的评估、制定和评价指南评估证据强度。将使用STATA V.16.0进行Meta分析，效应量使用标准化均差和95%置信区间计算。将使用Cochran's Q统计量评估异质性，使用I统计量测量不一致性。还将评估潜在的偏倚来源。
本系统评价所用数据将仅从已发表的研究中提取。无需额外的伦理批准和知情同意。本系统评价将发表在同行评审期刊上，并将在会议和大会上展示。
PROSPERO注册号：CRD42024545231。
