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本文引用的文献

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A SYRINGE CHURN FOR MAKING REPOSITORY EMULSIONS. ORIGINS, PRINCIPLES AND PERFORMANCE.一种用于制备长效乳剂的注射器搅拌器。起源、原理及性能。
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A simple device for making emulsified vaccines.一种用于制备乳化疫苗的简易装置。
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Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.节肢动物传播病毒的血凝及血凝抑制技术。
Am J Trop Med Hyg. 1958 Sep;7(5):561-73. doi: 10.4269/ajtmh.1958.7.561.
4
Development of arthritis, periarthritis and periostitis in rats given adjuvants.给予佐剂的大鼠关节炎、关节周围炎和骨膜炎的发展。
Proc Soc Exp Biol Med. 1956 Jan;91(1):95-101. doi: 10.3181/00379727-91-22179.
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Amyloidosis and renal lesion induced in mice by injection with Freund-type of adjuvant.通过注射弗氏佐剂在小鼠中诱导淀粉样变性和肾损伤。
Proc Soc Exp Biol Med. 1954 Jan;85(1):133-7. doi: 10.3181/00379727-85-20808.
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A plaque reduction test for dengue virus neutralizing antibodies.登革病毒中和抗体的蚀斑减少试验。
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Use of sarcoma 180/TG to prepare hyperimmune ascitic fluid in the mouse.使用肉瘤180/TG在小鼠体内制备高免疫腹水。
J Immunol. 1966 Apr;96(4):676-82.
8
The use of adjuvant and sarcoma 180 cells in the production of mouse hyperimmune ascitic fluids to arboviruses.佐剂和肉瘤180细胞在制备抗虫媒病毒小鼠超免疫腹水液中的应用。
Am J Trop Med Hyg. 1966 Mar;15(2):219-26. doi: 10.4269/ajtmh.1966.15.219.
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Labile serum factor and its effect on arbovirus neutralization.不稳定血清因子及其对虫媒病毒中和作用的影响。
Appl Microbiol. 1971 Jan;21(1):79-83. doi: 10.1128/am.21.1.79-83.1971.
10
Bacteriological and pathological study of animals given Freund adjuvant.给予弗氏佐剂的动物的细菌学和病理学研究。
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辅助疫苗对2型登革病毒免疫腹水产生的影响。

Effect of adjuvant vaccines on dengue virus type 2 immune ascitic fluid production.

作者信息

Gamble W C, George E H, Fears M B, Sanderlin D W, Chappell W A

出版信息

J Clin Microbiol. 1985 Mar;21(3):452-3. doi: 10.1128/jcm.21.3.452-453.1985.

DOI:10.1128/jcm.21.3.452-453.1985
PMID:3980697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC271685/
Abstract

In a comparison of dengue type 2 immune mouse ascitic fluid immunization schedules, a schedule in which adjuvant vaccines were not used produced neutralizing antibody titers that were specific and a mouse mortality rate that was lower, resulting in a greater yield of ascitic fluids. In the schedules in which emulsified adjuvant vaccines were used, the quality of the emulsion had little effect on antibody titer produced.

摘要

在对登革热2型免疫小鼠腹水免疫方案的比较中，未使用佐剂疫苗的方案产生了特异性的中和抗体滴度，且小鼠死亡率较低，从而产生了更高产量的腹水。在使用乳化佐剂疫苗的方案中，乳液质量对产生的抗体滴度影响不大。