Brisebois Matthew F, Gordon Ryan A, Zumbro Emily L, Sokoloski Matthew L, Duplanty Anthony A, Juma Shanil, Rigby Brandon R
Department of Human Performance and Health, University of South Carolina Upstate, Spartanburg, SC, USA.
School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX, USA.
Int J Exerc Sci. 2024 Dec 1;17(2):1444-1460. doi: 10.70252/XFJK8005. eCollection 2024.
The purpose of this study was to compare changes in circulating microRNAs -126 (c-miR-126) and -222 (c-miR-222) following acute serial concurrent exercise (SCE) and integrated concurrent exercise (ICE) sessions among young, sedentary adults. Ten males and 9 females completed the study procedures. For SCE, participants performed resistance exercise (RE) followed by aerobic exercise (AE), without mixing the two. For ICE, participants performed a brief bout of AE before each set of RE. Blood was collected before, immediately after (IP), and 1 h (1HR) after each exercise session. Expression of c-miR-126 significantly increased from baseline at IP (1.6-fold SCE, 2.1-fold ICE; = .037) and 1HR (1.8-fold SCE, 1.7-fold ICE; = .034) following both sessions, with no difference between the two sessions. Expression of c-miR-222 significantly increased from baseline at IP (1.7-fold SCE, 1.9-fold ICE; = .024) and 1HR (2.0-fold SCE, 1.6-fold ICE; = .038) following both sessions, with no difference between the two sessions. There were no differences in peak heart rate or average heart rate between the two workout sessions. Both SCE and ICE patterns appear equally effective at acutely increasing c-miR-126 and -222.
本研究的目的是比较在年轻的久坐不动成年人中，急性连续同时运动（SCE）和综合同时运动（ICE）后循环微小RNA -126（c-miR-126）和 -222（c-miR-222）的变化。10名男性和9名女性完成了研究程序。对于SCE，参与者先进行抗阻运动（RE），然后进行有氧运动（AE），两者不混合。对于ICE，参与者在每组RE之前先进行一小段AE。在每次运动前、运动后即刻（IP）和运动后1小时（1HR）采集血液。在两次运动后，c-miR-126的表达在IP时（SCE为1.6倍，ICE为2.1倍；P = 0.037）和1HR时（SCE为1.8倍，ICE为1.7倍；P = 0.034）均显著高于基线水平，且两次运动之间无差异。c-miR-222的表达在IP时（SCE为1.7倍，ICE为1.9倍；P = 0.024）和1HR时（SCE为2.0倍，ICE为1.6倍；P = 0.038）均显著高于基线水平，且两次运动之间无差异。两次锻炼之间的峰值心率或平均心率没有差异。SCE和ICE模式在急性增加c-miR-126和 -222方面似乎同样有效。
