Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Neurosci. 2023 Mar;26(3):517-527. doi: 10.1038/s41593-023-01260-4. Epub 2023 Feb 20.
Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.
在能够记录和刺激人类大脑深部活动的技术方面取得的进展，推动了神经科学领域的重大发现，并为神经和精神疾病的新型疗法的发展做出了贡献。然而，进一步的进展受到了设备限制的阻碍，因为在人类自由运动行为期间，无法记录单个神经元的活动。此外，目前已批准用于人类的可植入神经刺激设备，其刺激编程能力有限，全双工双向能力受限。在这项研究中，我们开发了一种可穿戴式双向闭环神经调节系统（Neuro-stack），并在人类的静止和活动行为期间使用它来记录单个神经元和局部场电位活动。Neuro-stack 与高度灵活和可定制的刺激能力相结合，为研究疾病的神经生理学基础、开发改进的响应式神经调节疗法、探索人类自然行为期间的大脑功能提供了机会，从而弥合了数十年的跨物种神经科学研究成果之间的差距。
