College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.
Adv Mater. 2022 Jul;34(27):e2108491. doi: 10.1002/adma.202108491. Epub 2022 Apr 28.
The primary roles of precision medicine are to perform real-time examination, administer on-demand medication, and apply instruments continuously. However, most current therapeutic systems implement these processes separately, leading to treatment interruption and limited recovery in patients. Personalized healthcare and smart medical treatment have greatly promoted research on and development of biosensing and drug-delivery integrated systems, with intelligent wearable medical devices (IWMDs) as typical systems, which have received increasing attention because of their non-invasive and customizable nature. Here, the latest progress in research on IWMDs is reviewed, including their mechanisms of integrating biosensing and on-demand drug delivery. The current challenges and future development directions of IWMDs are also discussed.
精准医疗的主要作用是实时检查、按需给药和持续应用器械。然而，目前大多数治疗系统分别执行这些过程，导致治疗中断和患者康复受限。个性化医疗保健和智能医疗极大地促进了生物传感和药物输送集成系统的研究和开发，智能可穿戴医疗设备（IWMD）作为典型系统，由于其非侵入性和可定制性而受到越来越多的关注。本文综述了 IWMD 在生物传感和按需药物输送集成方面的最新研究进展，包括其作用机制。还讨论了 IWMD 目前面临的挑战和未来的发展方向。
