中性粒细胞与白蛋白比值在手术治疗口腔鳞状细胞癌中的预后价值
Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma.
作者信息
Yu Ya-Yun, Lin Yu-Tsai, Chuang Hui-Ching, Chien Chih-Yen, Huang Tai-Lin, Fang Fu-Min, Tsai Yao-Te, Lu Hui, Tsai Ming-Hsien
机构信息
Department of Education, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
出版信息
Head Neck. 2023 Nov;45(11):2839-2850. doi: 10.1002/hed.27511. Epub 2023 Sep 12.
BACKGROUND
We aimed to evaluate the prognostic significance of preoperative neutrophil-to-albumin ratio (NAR) in oral squamous cell carcinoma (OSCC).
METHODS
A total of 622 patients with surgically treated OSCC were enrolled. NAR was defined as the absolute neutrophil count divided by the serum albumin level in peripheral blood before the radical surgery. Cox proportional hazards model were used to discover survival outcome-associated factors.
RESULTS
The optimal cut-off of NAR to predict overall survival (OS) was determined to be 0.1. In Cox model, high NAR was identified as an independent negative prognosticator of OS, cancer-specific survival, and recurrence-free survival (adjusted hazard ratio: 1.503, 1.958, and 1.727, respectively; all p < 0.05). The NAR-based nomogram accurately predicted OS (concordance index: 0.750).
CONCLUSION
Our study suggests that preoperative NAR is a convenient and effective prognostic marker for OSCC and NAR-based nomogram can be a promising prognostic tool in clinical setting.
背景
我们旨在评估术前中性粒细胞与白蛋白比值（NAR）在口腔鳞状细胞癌（OSCC）中的预后意义。
方法
共纳入622例接受手术治疗的OSCC患者。NAR定义为根治性手术前外周血中性粒细胞绝对计数除以血清白蛋白水平。采用Cox比例风险模型来发现与生存结局相关的因素。
结果
预测总生存期（OS）的NAR最佳截断值确定为0.1。在Cox模型中，高NAR被确定为OS、癌症特异性生存期和无复发生存期的独立阴性预后因素（调整后风险比分别为1.503、1.958和1.727；均p<0.05）。基于NAR的列线图能准确预测OS（一致性指数：0.750）。
结论
我们的研究表明，术前NAR是OSCC便捷有效的预后标志物，基于NAR的列线图可能成为临床中有前景的预后工具。
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