Modupe Oghenejoboh Ufuoma, Olatunde Sonibare Oluwadayo, Waseem Muhammad, Olusegun Ekundayo, Haq Sirajul, Alsaiari Ahad Amer, Razzokov Jamoliddin
Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan.
Heliyon. 2024 Dec 6;11(1):e40759. doi: 10.1016/j.heliyon.2024.e40759. eCollection 2025 Jan 15.
Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases. Nanoparticles of Ni/Fe and Ni/Fe/Zn were synthesized by hydrothermal reaction of extract with the respective metal chlorides, and were characterized using XRD, SEM, DLS, IR and UV- spectroscopy. The drug encapsulation and release profile of the ferrites was studied using curcumin as a test drug. the Anticancer and antidiabetic activities of the nanoparticles were investigated against MCF-7 breast cancer cell lines using the MTT assay and α-glucosidase enzyme inhibitory assay, respectively. The nanoparticles had high drug loading capacity (<10 %), promising cytotoxic activity against MCF-7 breast cancer cell lines and α-glucosidase inhibitory activities ranging between 5.6 and 13.4 μM comparable to standard drug acarbose (9.8 μM), respectively. mediated nanoparticles of Ni/Fe and Ni/Fe/Zn could be further explored as alternative therapeutic agents for cancer and diabetes.
传统药物未能应对癌症和糖尿病日益严峻的公共卫生挑战。植物化学共轭纳米颗粒正在提供更安全的治疗选择来应对这一全球挑战。镍、铁和锌的纳米颗粒因其磁性以及预防这些疾病发作或减缓其进展的能力而特别有用。通过提取物与相应金属氯化物的水热反应合成了Ni/Fe和Ni/Fe/Zn纳米颗粒，并使用XRD、SEM、DLS、IR和紫外光谱对其进行了表征。以姜黄素为测试药物研究了铁氧体的药物包封和释放情况。分别使用MTT法和α-葡萄糖苷酶抑制试验研究了纳米颗粒对MCF-7乳腺癌细胞系的抗癌和抗糖尿病活性。纳米颗粒具有较高的载药能力（<10%），对MCF-7乳腺癌细胞系具有良好的细胞毒性活性，α-葡萄糖苷酶抑制活性在5.6至13.4μM之间，分别与标准药物阿卡波糖（9.8μM）相当。Ni/Fe和Ni/Fe/Zn介导的纳米颗粒可进一步探索作为癌症和糖尿病的替代治疗剂。
