Zhang Qin, Cheng Dangdang, Wang Feifei
Shanghai Jiyan Biomedical Development Co., Ltd., 9th Floor, Building B, No.999 Huaxu Road, Shanghai, 201702, China.
Yunnan Botanee Bio-technology Group Co., Ltd., Yunnan, 650106, China.
Sci Rep. 2025 Jan 14;15(1):1935. doi: 10.1038/s41598-025-86467-0.
This study aimed to develop in vivo methods for assessing facial anti-glycation and anti-aging effects and to investigate the link between glycation and aging signs. We utilized an AGE reader to measure AGEs levels on the face and arms, establishing a correlation to validate the reader's use for facial AGEs detection. Then the product's 7-day anti-glycation effect was evaluated. And its 56-day anti-aging effects were evaluated using non-invasive probes and VISIA CR, assessing skin tone (skin brightness L* and yellowness b*, skin gloss), texture (skin elasticity R2 and firmness F4, skin pores), and hydration (skin moisture content). Correlations between facial AGEs levels and aging parameters were analyzed. Results indicated a strong correlation between facial and arm AGEs after product application, supporting facial AGEs level as an assessment parameter. The product demonstrated substantial anti-glycation and anti-aging effects, suggesting the methods' efficacy for cosmetic evaluation. A stronger overall correlation was found between AGEs levels and skin tone than with skin texture and hydration, highlighting glycation's impact on skin color.
本研究旨在开发用于评估面部抗糖化和抗衰老效果的体内方法，并研究糖化与衰老迹象之间的联系。我们使用了一种晚期糖基化终末产物（AGE）阅读器来测量面部和手臂上的AGEs水平，建立相关性以验证该阅读器用于面部AGEs检测的用途。然后评估了该产品的7天抗糖化效果。并使用非侵入性探头和VISIA CR评估了其56天的抗衰老效果，评估内容包括肤色（皮肤亮度L和黄度b、皮肤光泽度）、质地（皮肤弹性R2和紧致度F4、皮肤毛孔）和水合作用（皮肤水分含量）。分析了面部AGEs水平与衰老参数之间的相关性。结果表明，产品应用后面部和手臂的AGEs之间存在很强的相关性，支持将面部AGEs水平作为评估参数。该产品显示出显著的抗糖化和抗衰老效果，表明这些方法在化妆品评估方面的有效性。与皮肤质地和水合作用相比，AGEs水平与肤色之间的总体相关性更强，突出了糖化对皮肤颜色的影响。
