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具有自噬刺激活性的新合成抗氧化剂的抗糖化和抗衰老功效

Anti-Glycation and Anti-Aging Efficacy of Newly Synthesized Antioxidant With Autophagy Stimulating Activity.

作者信息

Shin Kayoung, Kim Yeonjae, Kim Sungwoo, Jung Kim Hyun, Jeong Sekyoo, Jang Mi, Park Jeong Ho, Nam Gaewon

机构信息

Research Team, Incospharm Corp, Daejeon, South Korea.

Department of Dermatology, Chungnam National University Sejong Hospital, Sejong, South Korea.

出版信息

J Cosmet Dermatol. 2025 May;24(5):e70240. doi: 10.1111/jocd.70240.

DOI:10.1111/jocd.70240
PMID:40387285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12087425/
Abstract

BACKGROUND

The accumulation of advanced glycation end products (AGEs) in aged skin and their pro-aging effects suggest the potential application of anti-glycation ingredients as skin anti-aging agents.

AIMS

This study evaluated the anti-aging efficacy of a newly developed anti-glycation ingredient with antioxidant and autophagy-stimulating activities through in vitro, ex vivo, and clinical efficacy tests.

METHODS

AGEs formation in both the cell-free BSA/glyoxal system and glucose/glyoxal-treated human epidermal keratinocytes was measured, while the degradation of pre-formed BSA/AGEs by keratinocytes was assessed. Anti-glycation and anti-inflammatory effects were further examined using an ex vivo human skin explant model. Clinical anti-aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.

RESULTS

The tested ingredient inhibited AGE formation and accelerated the degradation of pre-formed AGEs in vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4 weeks of test product application.

CONCLUSION

A newly synthesized antioxidant with autophagy-stimulating activity exhibited significant anti-glycation efficacy in both in vitro and clinical studies, suggesting its potential as an effective skin anti-aging ingredient.

摘要

背景

晚期糖基化终末产物（AGEs）在衰老皮肤中的积累及其促衰老作用表明，抗糖基化成分作为皮肤抗衰老剂具有潜在应用价值。

目的

本研究通过体外、离体和临床疗效试验，评估一种新开发的具有抗氧化和自噬刺激活性的抗糖基化成分的抗衰老功效。

方法

测量无细胞牛血清白蛋白/乙二醛系统以及葡萄糖/乙二醛处理的人表皮角质形成细胞中AGEs的形成，同时评估角质形成细胞对预先形成的牛血清白蛋白/AGEs的降解。使用离体人皮肤外植体模型进一步检测抗糖基化和抗炎作用。通过评估皮肤AGE水平、黑色素和红斑指数、皮肤弹性和皮肤水合水平来分析临床抗衰老效果。

结果

受试成分在体外抑制AGE形成并加速预先形成的AGEs的降解。在应用测试产品2周和4周后，观察到健康志愿者的皮肤AGE水平显著降低、皮肤黑色素和红斑指数降低，以及皮肤弹性和水合作用改善。

结论

一种新合成的具有自噬刺激活性的抗氧化剂在体外和临床研究中均表现出显著的抗糖基化功效，表明其作为一种有效的皮肤抗衰老成分的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/23cc11cf0ea5/JOCD-24-e70240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/a5dca9936e68/JOCD-24-e70240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/6ec4c5862c2e/JOCD-24-e70240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/d5672103d695/JOCD-24-e70240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/69dc231a1ead/JOCD-24-e70240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/76918972332f/JOCD-24-e70240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/23cc11cf0ea5/JOCD-24-e70240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/a5dca9936e68/JOCD-24-e70240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/6ec4c5862c2e/JOCD-24-e70240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/d5672103d695/JOCD-24-e70240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/69dc231a1ead/JOCD-24-e70240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/76918972332f/JOCD-24-e70240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8c/12087425/23cc11cf0ea5/JOCD-24-e70240-g006.jpg

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本文引用的文献

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