Martinovic Dinko, Tokic Daria, Usljebrka Mislav, Lupi-Ferandin Slaven, Cigic Livia, Vanjaka Rogosic Lucija, Ercegovic Sasa, Kontic Mirko, Kumrić Marko, Rusic Doris, Vilovic Marino, Leskur Mateo, Bozic Josko
Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia.
Department of Anesthesiology and Intensive Care, University Hospital of Split, 21000 Split, Croatia.
Life (Basel). 2023 Jan 17;13(2):256. doi: 10.3390/life13020256.
Advanced glycation end products (AGEs) represent an endogenously produced or exogenously derived group of compounds derived from nonenzymatic glycation. Recent experimental studies are suggesting that AGEs could play an important role in the skin's quality and its aging process. Hence, the aim of this study was to clinically evaluate the AGEs and skin quality parameters across different age groups in the general population. The study included 237 participants. Melanin, erythema, hydration, friction and transepidermal water loss (TEWL) were evaluated using noninvasive probes, while AGEs were evaluated using a skin autofluorescence reader. There was a significant positive correlation between AGEs and the amount of melanin ( < 0.001), erythema ( < 0.001) and TEWL ( < 0.001), while there was a significant negative correlation between AGEs and hydration ( < 0.001) and friction ( < 0.001). After dividing the sample into three groups depending on their age, in all three groups, there was a significant positive correlation between AGEs and the melanin count ( < 0.001) and TEWL ( < 0.001), while there was a significant negative correlation between AGEs and skin hydration ( < 0.001). Multiple linear regression analysis showed that the level of AGEs as a dependent variable retained a significant association with age ( < 0.001), melanin ( < 0.001), erythema ( = 0.005) and TEWL ( < 0.001) as positive predictors. Moreover, AGEs retained a significant association with skin hydration ( < 0.001) and friction ( = 0.017) as negative predictors. These outcomes imply that AGEs could be linked with the complex physiology of the skin and its aging process.
晚期糖基化终末产物（AGEs）是一组内源性产生或外源性衍生的、源自非酶糖基化的化合物。最近的实验研究表明，AGEs可能在皮肤质量及其衰老过程中发挥重要作用。因此，本研究的目的是对普通人群中不同年龄组的AGEs和皮肤质量参数进行临床评估。该研究纳入了237名参与者。使用非侵入性探头评估黑色素、红斑、水合作用、摩擦力和经表皮水分流失（TEWL），同时使用皮肤自发荧光阅读器评估AGEs。AGEs与黑色素量（<0.001）、红斑（<0.001）和TEWL（<0.001）之间存在显著正相关，而AGEs与水合作用（<0.001）和摩擦力（<0.001）之间存在显著负相关。根据年龄将样本分为三组后，在所有三组中，AGEs与黑色素计数（<0.001）和TEWL（<0.001）之间存在显著正相关，而AGEs与皮肤水合作用（<0.001）之间存在显著负相关。多元线性回归分析表明，作为因变量的AGEs水平与年龄（<0.001）、黑色素（<0.001）、红斑（=0.005）和TEWL（<0.001）作为正向预测因子保持显著关联。此外，AGEs与皮肤水合作用（<0.001）和摩擦力（=0.017）作为负向预测因子保持显著关联。这些结果表明，AGEs可能与皮肤的复杂生理及其衰老过程有关。
