Chen Chun-Yu, Zhang Jia-Qi, Li Li, Guo Miao-Miao, He Yi-Fan, Dong Yin-Mao, Meng Hong, Yi Fan
Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing, China.
Front Med (Lausanne). 2022 May 11;9:837222. doi: 10.3389/fmed.2022.837222. eCollection 2022.
Advanced glycation end products (AGEs) are a series of stable compounds produced under non-enzymatic conditions by the amino groups of biomacromolecules and the free carbonyl groups of glucose or other reducing sugars commonly produced by thermally processed foods. AGEs can cause various diseases, such as diabetes, atherosclerosis, neurodegeneration, and chronic kidney disease, by triggering the receptors of AGE (RAGEs) in the human body. There is evidence that AGEs can also affect the different structures and physiological functions of the skin. However, the mechanism is complicated and cumbersome and causes various harms to the skin. This article aims to identify and summarise the formation and characteristics of AGEs, focussing on the molecular mechanisms by which AGEs affect the composition and structure of normal skin substances at different skin layers and induce skin issues. We also discuss prevention and inhibition pathways, provide a systematic and comprehensive method for measuring the content of AGEs in human skin, and summarise and analyse their advantages and disadvantages. This work can help researchers acquire a deeper understanding of the relationship between AGEs and the skin and provides a basis for the development of effective ingredients that inhibit glycation.
晚期糖基化终末产物（AGEs）是生物大分子的氨基与葡萄糖或其他还原糖的游离羰基在非酶促条件下反应生成的一系列稳定化合物，这些还原糖通常由热加工食品产生。AGEs可通过激活人体中的AGE受体（RAGEs）引发多种疾病，如糖尿病、动脉粥样硬化、神经退行性变和慢性肾脏病。有证据表明，AGEs还会影响皮肤的不同结构和生理功能。然而，其作用机制复杂且繁琐，会对皮肤造成多种损害。本文旨在识别和总结AGEs的形成及特征，重点关注AGEs影响不同皮肤层正常皮肤物质的组成和结构并引发皮肤问题的分子机制。我们还讨论了预防和抑制途径，提供了一种系统、全面的方法来测量人体皮肤中AGEs的含量，并总结分析了其优缺点。这项工作有助于研究人员更深入地了解AGEs与皮肤之间的关系，并为开发抑制糖基化的有效成分提供依据。
