Luo Yang-Gang, Wu Mei, Chen Hong-Guang
Pathology Department, Xuanhan County People's Hospital, Dazhou 636150, Sichuan Province, China.
World J Gastrointest Oncol. 2025 Jan 15;17(1):99153. doi: 10.4251/wjgo.v17.i1.99153.
Pancreatic cancer remains one of the most lethal malignancies worldwide, with a poor prognosis often attributed to late diagnosis. Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.
To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.
We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution. Pathological types were determined by histopathological examination of the surgical specimens or biopsy samples. The imaging features were assessed using computed tomography, magnetic resonance imaging, and endoscopic ultrasound. Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.
There were 320 (64%) cases of pancreatic ductal adenocarcinoma, 75 (15%) of intraductal papillary mucinous neoplasms, 50 (10%) of neuroendocrine tumors, and 55 (11%) of other rare types. Distinct imaging features were identified in each pathological type. Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography, whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules. Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging. Statistical analysis revealed significant correlations between specific imaging features and pathological types ( < 0.001).
This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features. These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
胰腺癌仍然是全球最致命的恶性肿瘤之一，预后不良通常归因于诊断较晚。了解病理类型与影像学特征之间的相关性对于早期检测和制定合适的治疗方案至关重要。
回顾性分析不同病理类型的胰腺癌与其相应影像学特征之间的关系。
我们回顾性分析了2010年1月至2020年12月在我院诊断为胰腺癌的500例患者的数据。病理类型通过手术标本或活检样本的组织病理学检查确定。使用计算机断层扫描、磁共振成像和内镜超声评估影像学特征。进行统计分析以确定病理类型与特定影像学特征之间的显著关联。
有320例（64%）胰腺导管腺癌，75例（15%）导管内乳头状黏液性肿瘤，50例（10%）神经内分泌肿瘤，以及55例（11%）其他罕见类型。在每种病理类型中都发现了不同的影像学特征。胰腺导管腺癌在计算机断层扫描上通常表现为边界不清的低密度肿块，而导管内乳头状黏液性肿瘤表现为具有壁结节的特征性囊性病变。神经内分泌肿瘤在增强成像中常表现为高血运病变。统计分析显示特定影像学特征与病理类型之间存在显著相关性（<0.001）。
本研究表明胰腺癌的病理类型与影像学特征之间存在密切关联。这些发现可以提高无创诊断的准确性并指导个性化治疗方法。
