Bu Hanli, Lv Mingzhen, Wang Linxian, Jiang Dan, Ding Yi, Wang Zheya, Hu Yaoyao, Zhuang Qin, Tian Zhenzhen
Department of General Practice, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Gastrointestinal Surgery, Guilin Medical University Affiliated Hospital, Guilin, China.
PLoS One. 2025 Jan 17;20(1):e0316819. doi: 10.1371/journal.pone.0316819. eCollection 2025.
The rising prevalence of depression among cancer patients is alarming. This study examines the relationship between the Oxidative Balance Score (OBS)-a composite measure of dietary and lifestyle factors-and depression, including specific depressive symptoms in this population.
Data were analyzed from 3,280 adult cancer patients collected in NHANES from 2005-2020. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), where a score of 10 or above indicated depression. Symptoms experienced frequently were classified as specific depressive symptoms. Weighted logistic regression models were utilized to explore the correlation between OBS and depression, along with distinctive depressive symptoms.
There was a negative correlation between OBS and depression. The highest quartile of OBS (OR 0.313, 95% CI: 0.161-0.609), along with dietary OBS (OR 0.429, 95% CI: 0.234-0.786) and the third quartile of lifestyle OBS (OR 0.404, 95% CI: 0.226-0.722), was associated with reduced depression risk. OBS was correlated with lower risks of all four somatic depressive symptoms and one cognitive symptom. Dietary OBS was associated with fewer risks of three somatic symptoms and one cognitive symptom. Lifestyle OBS showed a negative correlation with two somatic symptoms. Stratified analyses indicated that the inverse relationship between OBS and depression risk was consistent across subgroups, including females and individuals under 65. a nonlinear association was observed between OBS (p = 0.024), dietary OBS (p<0.001), lifestyle OBS (p = 0.021), and depression.
OBS is inversely related to depression and specific depressive symptoms in cancer patients. Encouraging a diet and lifestyle rich in antioxidants may help reduce the risk of depression in this group.
癌症患者中抑郁症患病率的上升令人担忧。本研究探讨氧化平衡评分（OBS）——一种饮食和生活方式因素的综合指标——与抑郁症之间的关系，包括该人群中的特定抑郁症状。
对2005年至2020年美国国家健康与营养检查调查（NHANES）收集的3280名成年癌症患者的数据进行分析。使用患者健康问卷-9（PHQ-9）评估抑郁症，得分10分及以上表明患有抑郁症。经常出现的症状被归类为特定抑郁症状。采用加权逻辑回归模型探讨OBS与抑郁症以及独特抑郁症状之间的相关性。
OBS与抑郁症之间存在负相关。OBS的最高四分位数（比值比[OR]0.313，95%置信区间[CI]：0.161 - 0.609），以及饮食OBS（OR 0.429，95% CI：0.234 - 0.786）和生活方式OBS的第三四分位数（OR 0.404，95% CI：0.226 - 0.722）与降低抑郁症风险相关。OBS与所有四种躯体抑郁症状和一种认知症状的较低风险相关。饮食OBS与三种躯体症状和一种认知症状的较少风险相关。生活方式OBS与两种躯体症状呈负相关。分层分析表明，OBS与抑郁症风险之间的反向关系在各亚组中一致，包括女性和65岁以下个体。观察到OBS（p = 0.024）、饮食OBS（p<0.001）、生活方式OBS（p = 0.021）与抑郁症之间存在非线性关联。
OBS与癌症患者的抑郁症及特定抑郁症状呈负相关。鼓励富含抗氧化剂的饮食和生活方式可能有助于降低该群体患抑郁症的风险。
