Zhu Xinhui, Zhang Lipeng, Qi Yingcheng, Zhang Jingyu, Tang Fuxin, Zong Zhen
Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Department of General Surgery (Hernia and Abdominal Wall Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Colloids Surf B Biointerfaces. 2025 May;249:114511. doi: 10.1016/j.colsurfb.2025.114511. Epub 2025 Jan 14.
Abdominal adhesions are a frequent complication after abdominal surgery, which can cause significant pain and burden to patients. Despite various treatment options, including surgical intervention and pharmacotherapy, these often fail to consistently and effectively prevent postoperative abdominal adhesions. Janus hydrogel is famous for its asymmetric characteristics, which shows great prospects in the prevention and treatment of abdominal adhesion. This review outlines the preparation methods, mechanisms of action, and key applications of Janus hydrogel in the prevention of postoperative abdominal adhesions. Furthermore, we examine the current limitations of the Janus hydrogel anti-adhesion barrier and explore potential future directions for its development.
腹部粘连是腹部手术后常见的并发症，会给患者带来巨大疼痛和负担。尽管有多种治疗选择，包括手术干预和药物治疗，但这些方法往往无法持续有效地预防术后腹部粘连。双面水凝胶因其不对称特性而闻名，在预防和治疗腹部粘连方面显示出巨大前景。本文综述了双面水凝胶在预防术后腹部粘连方面的制备方法、作用机制和关键应用。此外，我们还研究了双面水凝胶抗粘连屏障目前的局限性，并探索其未来潜在的发展方向。
