McCaig Colin D
Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
Rev Physiol Biochem Pharmacol. 2025;187:361-410. doi: 10.1007/978-3-031-68827-0_18.
One of the most important and challenging biological events of recent times has been the pandemic caused by SARS-CoV-2. Since the underpinning argument behind this book is the ubiquity of electrical forces driving multiple disparate biological events, consideration of key aspects of the SARS-CoV-2 structural proteins is included. Electrical regulation of spike protein, nucleocapsid protein, membrane protein, and envelope protein is included, with several of their activities regulated by LLPS and the multivalent and π-cation and π-π electrical forces that drive phase separation.
近年来最重要且最具挑战性的生物学事件之一是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发的大流行。由于本书的基本论点是驱动多种不同生物学事件的电力无处不在,因此本文将探讨SARS-CoV-2结构蛋白的关键方面。本文涵盖了刺突蛋白、核衣壳蛋白、膜蛋白和包膜蛋白的电调节,其中它们的一些活性由液-液相分离(LLPS)以及驱动相分离的多价、π-阳离子和π-π电力调节。