Milner A E, Burnett D, Rutter J, Bradwell A R
Thromb Res. 1985 Jan 1;37(1):127-34. doi: 10.1016/0049-3848(85)90039-8.
Antithrombin III microheterogeneity was investigated by isoelectric focusing and immunofixation in healthy individuals and in patients with clinical conditions in which antithrombin III is known to vary (liver disease, nephrotic syndrome, after surgery and anticoagulant therapy). In normal plasma microheterogeneity was present with ten bands of varying intensity being visible in a pI range from 5.0-5.7. One variant was observed which was not associated with a clinical disorder. Low concentrations of antithrombin III were detected in some patients with liver disease, nephrotic syndrome and those on anticoagulant therapy and these demonstrated a decrease of intensity in all bands. Alterations in microheterogeneity were seen in patients tested after surgery and those with nephrotic syndrome. This indicates that changes in the subpopulations of antithrombin III can occur and may be relevant to clinical abnormalities.
通过等电聚焦和免疫固定法，对健康个体以及患有已知抗凝血酶III水平会发生变化的临床疾病（肝病、肾病综合征、术后及抗凝治疗后）的患者进行了抗凝血酶III微观异质性研究。在正常血浆中存在微观异质性，在pH值范围5.0 - 5.7内可见十条强度各异的条带。观察到一种变体，其与临床疾病无关。在一些肝病、肾病综合征患者以及接受抗凝治疗的患者中检测到低浓度的抗凝血酶III，且所有条带的强度均降低。术后检测的患者以及肾病综合征患者出现了微观异质性改变。这表明抗凝血酶III亚群可能会发生变化，且可能与临床异常情况相关。
