Lau S O, Tkachuck J Y, Hasegawa D K, Edson J R
J Pediatr. 1980 Mar;96(3 Pt 1):390-2. doi: 10.1016/s0022-3476(80)80678-0.
Three of four patients with the childhood nephrotic syndrome were found to have low plasma plasminogen concentrations; all four had low plasma antithrombin III concentrations. In the two patients who were tested, urinary concentrations of these proteins exceeded the plasma concentrations. As the urinary losses of plasminogen and antithrombin III decreased over the course of illness, the plasma concentrations of antithrombin III and plasminogen rose. One patient had multiple thromboembolic episodes. We conclude the deficiencies of antithrombin III and plasminogen, probably secondary to urinary excretion of these proteins, may contribute to the thrombotic diathesis associated with nephrotic syndrome.
在四名患有儿童肾病综合征的患者中，有三名被发现血浆纤溶酶原浓度较低；四名患者的血浆抗凝血酶III浓度均较低。在接受检测的两名患者中，这些蛋白质的尿液浓度超过了血浆浓度。随着疾病过程中纤溶酶原和抗凝血酶III的尿流失减少，抗凝血酶III和纤溶酶原的血浆浓度升高。一名患者发生了多次血栓栓塞事件。我们得出结论，抗凝血酶III和纤溶酶原的缺乏可能继发于这些蛋白质的尿排泄，可能导致与肾病综合征相关的血栓形成倾向。
