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一组黎巴嫩老年人中的痴呆症发病率:中东和北非地区的首次发病率估计

Dementia incidence among a cohort of lebanese older adults: first incidence estimates from the Middle East and North Africa region.

作者信息

Chaaya Monique, Assaad Sarah, Darwish Hala, Haber Marc, Khoury Rosemary, Saab Dahlia, El Asmar Khalil, Hajjar Ramzi

机构信息

Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon.

Research Department of Epidemiology and Public Health, University College London, London, United Kingdom.

出版信息

Front Dement. 2025 Jan 7;3:1494719. doi: 10.3389/frdem.2024.1494719. eCollection 2024.

Abstract

OBJECTIVE

To provide the first estimates of dementia incidence rates among elderly in Lebanon.

METHODS

The cohort established in 2013 consisted of 470 elderly from Beirut and Mount Lebanon, who consented to be followed-up. In 2017, we reached 341 participants/informants, achieving a response rate of 72.6%. The validated Arabic version of the 10/66 Dementia Research Group diagnostic tool was administered through face-to-face interviews. Direct age standardization was applied to the data using the Western European population distribution. Age-, sex- and location-specific incidence rates were estimated.

RESULTS

After 3.5 years of follow up, 19 new cases of dementia were identified among 229 surviving participants. The crude incidence rate was 16.8 per 1,000 p-y, and the age standardized rate was 20.5 per 1,000 p-y. The incidence rate increased with age, going from 6.5 for those aged 65-74 years to 54.0 for those aged 85-89 years. Incidence rate was higher among females than males (20.7 vs.12.0), and higher in Mount Lebanon, as compared to the capital city Beirut (19.5 vs.14.9).

CONCLUSION

Dementia incidence rate was close to European and North American countries' estimates. The use of validated tools increased the internal validity of our results. A large cohort study is warranted to confirm these results.

摘要

目的

提供黎巴嫩老年人痴呆症发病率的首次估算。

方法

2013年建立的队列由来自贝鲁特和黎巴嫩山的470名老年人组成,他们同意接受随访。2017年,我们联系到了341名参与者/信息提供者,应答率为72.6%。通过面对面访谈使用经验证的10/66痴呆症研究小组诊断工具的阿拉伯语版本。使用西欧人口分布对数据进行直接年龄标准化。估算了年龄、性别和地点特异性发病率。

结果

经过3.5年的随访,在229名存活的参与者中确定了19例新的痴呆症病例。粗发病率为每1000人年16.8例,年龄标准化发病率为每1000人年20.5例。发病率随年龄增长而增加,从65 - 74岁人群的6.5例增至85 - 89岁人群的54.0例。女性的发病率高于男性(20.7对12.0),与首都贝鲁特相比,黎巴嫩山的发病率更高(19.5对14.9)。

结论

痴呆症发病率接近欧洲和北美国家的估算值。使用经验证的工具提高了我们结果的内部效度。有必要开展一项大型队列研究来证实这些结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc95/11745875/4e9b9ba257f8/frdem-03-1494719-g0001.jpg

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