针对抗生素耐药性的药物组合。

Bognár Bence, Spohn Réka, Lázár Viktória

HCEMM-BRC Pharmacodynamic Drug Interaction Research Group, Szeged, Hungary.

Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.

NPJ Antimicrob Resist. 2024 Oct 3;2(1):29. doi: 10.1038/s44259-024-00047-2.

While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to combat antibiotic resistance. In this review we discuss how drug combinations can exploit the deleterious pleiotropic effects of antibiotic resistance and conclude that each drug interaction has its prospective therapeutic application.

虽然抗生素耐药性的上升构成了全球健康挑战，但在过去几十年中，新型抗生素的研发速度已经放缓。这使得研究人员将注意力转向合理设计联合药物疗法以对抗抗生素耐药性。在本综述中，我们讨论了联合药物如何利用抗生素耐药性的有害多效性，并得出结论：每种药物相互作用都有其潜在的治疗应用。