Hashem Mona M, Hassanen Eman I, Hassan Neven H, Ibrahim Marwa A, Issa Marwa Y, Farag Mohamed A, Hamdy Sherif A
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini st, P.B. 11562, Cairo, Egypt.
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
BMC Complement Med Ther. 2025 Jan 22;25(1):21. doi: 10.1186/s12906-025-04750-z.
Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats.
Rats were divided into 6 groups including control, PP-treated, HFM-exposed, and co-treated (HFM + PP) groups. Immune function, antioxidant activity, and organ damage were assessed. Furthermore, UPLC-MS/MS analysis identified potential bioactive compounds in PP extract.
HFM exposure suppressed immune responses and caused organ damage. Notably, the co-administration of PP extract with HFM reversed these effects, indicating its ability to reduce oxidative stress and protect the immune system. UPLC-MS/MS analysis of PP calyces ethanolic extract revealed its richness in various health-promoting metabolites, including acyl sucrose sugar, withanolides, and flavonoids, which may provide valuable insight into the underlying mechanisms of PP's calyces protective effects against HFM toxicity.
This study provides novel insights into the potential of P. peruviana L. calyces ethanolic extract as a natural agent to counteract the harmful effects of HFM exposure. These findings have significant implications for developing effective strategies to mitigate pesticide-induced toxicity and promote human health.
六氟脲（HFM）是一种常见的杀虫剂，可扰乱免疫系统并导致氧化应激。本研究调查了灯笼草萼片提取物（PP）抵消大鼠体内这些影响的潜力。
将大鼠分为6组，包括对照组、PP处理组、HFM暴露组和联合处理组（HFM + PP）。评估免疫功能、抗氧化活性和器官损伤。此外，超高效液相色谱-串联质谱（UPLC-MS/MS）分析确定了PP提取物中的潜在生物活性化合物。
HFM暴露抑制了免疫反应并导致器官损伤。值得注意的是，PP提取物与HFM联合给药可逆转这些影响，表明其具有减轻氧化应激和保护免疫系统的能力。对PP萼片乙醇提取物的UPLC-MS/MS分析表明，其富含多种促进健康的代谢物，包括酰基蔗糖糖、睡茄内酯和黄酮类化合物，这可能为PP萼片对HFM毒性的保护作用的潜在机制提供有价值的见解。
本研究为灯笼草萼片乙醇提取物作为一种天然剂抵消HFM暴露的有害影响的潜力提供了新的见解。这些发现对于制定有效的策略以减轻农药诱导的毒性和促进人类健康具有重要意义。
