Smith Dallas J, Gold Jeremy A W, Benedict Kaitlin, Wu Karen, Lyman Meghan, Jordan Alexander, Medina Narda, Lockhart Shawn R, Sexton D Joseph, Chow Nancy A, Jackson Brendan R, Litvintseva Anastasia P, Toda Mitsuru, Chiller Tom
Mycotic Diseases Branch, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
J Fungi (Basel). 2023 Aug 3;9(8):820. doi: 10.3390/jof9080820.
Fungal infections can cause severe disease and death and impose a substantial economic burden on healthcare systems. Public health research requires a multidisciplinary approach and is essential to help save lives and prevent disability from fungal diseases. In this manuscript, we outline the main public health research priorities for fungal diseases, including the measurement of the fungal disease burden and distribution and the need for improved diagnostics, therapeutics, and vaccines. Characterizing the public health, economic, health system, and individual burden caused by fungal diseases can provide critical insights to promote better prevention and treatment. The development and validation of fungal diagnostic tests that are rapid, accurate, and cost-effective can improve testing practices. Understanding best practices for antifungal prophylaxis can optimize prevention in at-risk populations, while research on antifungal resistance can improve patient outcomes. Investment in vaccines may eliminate certain fungal diseases or lower incidence and mortality. Public health research priorities and approaches may vary by fungal pathogen.
真菌感染可导致严重疾病和死亡，并给医疗系统带来沉重的经济负担。公共卫生研究需要多学科方法，对于帮助挽救生命和预防真菌疾病导致的残疾至关重要。在本手稿中，我们概述了真菌疾病主要的公共卫生研究重点，包括真菌疾病负担和分布的衡量，以及改进诊断、治疗和疫苗的必要性。了解真菌疾病造成的公共卫生、经济、卫生系统和个人负担可为促进更好的预防和治疗提供关键见解。开发和验证快速、准确且经济高效的真菌诊断测试可改善检测实践。了解抗真菌预防的最佳做法可优化高危人群的预防工作，而对抗真菌耐药性的研究可改善患者预后。对疫苗的投资可能消除某些真菌疾病或降低发病率和死亡率。公共卫生研究重点和方法可能因真菌病原体而异。
