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组胺不耐受:症状、诊断及其他。

Histamine Intolerance: Symptoms, Diagnosis, and Beyond.

作者信息

Jochum Christoph

机构信息

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Hepatology and Gastroenterology, Campus Charité Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany.

出版信息

Nutrients. 2024 Apr 19;16(8):1219. doi: 10.3390/nu16081219.

DOI:10.3390/nu16081219
PMID:38674909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11054089/
Abstract

Histamine intolerance is a condition characterized by the accumulation of histamine to a point that exceeds the body's capacity to eliminate it. Researchers have attributed several reasons to this condition, such as genetic factors, alcohol, and dietary deficiencies, among other elements. Symptoms of histamine intolerance have been found to extend beyond the gastrointestinal tract and to the whole body, with these symptoms being sporadic and non-specific. This review will explore various aspects related to histamine intolerance, such as its causes, symptoms, diagnosis, and information related to management.

摘要

组胺不耐受是一种以组胺积累到超过身体消除能力为特征的病症。研究人员将这种情况归因于多种原因,如遗传因素、酒精和饮食缺乏等其他因素。已发现组胺不耐受的症状不仅限于胃肠道,而是会影响全身,且这些症状是偶发性的和非特异性的。本综述将探讨与组胺不耐受相关的各个方面,如病因、症状、诊断以及管理相关信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/11054089/54cc1c5ee55a/nutrients-16-01219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/11054089/1361d8a7873f/nutrients-16-01219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/11054089/54cc1c5ee55a/nutrients-16-01219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/11054089/1361d8a7873f/nutrients-16-01219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/11054089/54cc1c5ee55a/nutrients-16-01219-g002.jpg

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本文引用的文献

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Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance.血清二胺氧化酶评估作为组胺不耐受的诊断试验。
Nutrients. 2023 Oct 2;15(19):4246. doi: 10.3390/nu15194246.
2
Food Intolerance: The Role of Histamine.食物不耐受:组胺的作用。
Nutrients. 2021 Sep 15;13(9):3207. doi: 10.3390/nu13093207.
3
Histamine Intolerance-The More We Know the Less We Know. A Review.组胺不耐受——了解越多,困惑越多。一篇综述。
Cureus. 2025 Mar 16;17(3):e80649. doi: 10.7759/cureus.80649. eCollection 2025 Mar.
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The Prevalence of Single Nucleotide Polymorphisms of the Gene Associated with Diamine Oxidase (DAO) Enzyme Deficiency in Healthy Newborns: A Prospective Population-Based Cohort Study.健康新生儿中与二胺氧化酶(DAO)酶缺乏相关基因的单核苷酸多态性患病率:一项基于人群的前瞻性队列研究。
Genes (Basel). 2025 Jan 24;16(2):141. doi: 10.3390/genes16020141.
5
Spectrum, Time Course, Stages, and a Proposal for the Diagnosis of Histamine Intolerance in General Practice: A Nonrandomized, Quasi-Experimental Study.全科医疗中组胺不耐受的诊断范围、时间进程、阶段及建议:一项非随机、准实验研究
J Clin Med. 2025 Jan 7;14(2):311. doi: 10.3390/jcm14020311.
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Comorbidity of Histamine Intolerance and Polyvalent Allergy: A Case Report and Literature Review.组胺不耐受与多价过敏的共病:一例报告及文献综述
Healthcare (Basel). 2025 Jan 7;13(2):94. doi: 10.3390/healthcare13020094.
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Alcohol in Daily Products: Health Risks, Cultural Considerations, and Economic Impacts.日常用品中的酒精:健康风险、文化考量及经济影响。
Risk Manag Healthc Policy. 2025 Jan 18;18:217-237. doi: 10.2147/RMHP.S495493. eCollection 2025.
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Study Protocol for a Prospective, Unicentric, Double-Blind, Randomized, and Placebo-Controlled Trial on the Efficacy of a Low-Histamine Diet and DAO Enzyme Supplementation in Patients with Histamine Intolerance.一项关于低组胺饮食和补充DAO酶对组胺不耐受患者疗效的前瞻性、单中心、双盲、随机、安慰剂对照试验的研究方案。
Nutrients. 2024 Dec 25;17(1):29. doi: 10.3390/nu17010029.
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