Li Aikang, Liang Rongji, Wu Liangbin, Cai Minghua, Chen Jiayou, Gong Yao, Zeng Shaoyin
Shantou University Medical College, Shantou, China.
Shenzhen University Medical College, Shenzhen University, Shenzhen, China.
Front Med (Lausanne). 2025 Jan 8;11:1499798. doi: 10.3389/fmed.2024.1499798. eCollection 2024.
This study aimed to evaluate the health-related quality of life (HRQoL) in ankylosing spondylitis (AS) patients in the Chaoshan region and identify factors influencing the ASAS Health Index (ASAS-HI) to enhance comprehensive AS treatment strategies.
A survey of ASAS-HI was conducted on 82 AS patients from the rheumatology outpatient department of the First Affiliated Hospital of Shantou University Medical College. The Bath Ankylosing Spondylitis Global Score (BAS-G) assessed overall health status, the Ankylosing Spondylitis Quality of Life Questionnaire (AS-QOL) evaluated quality of life, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) measured disease activity, and the Bath Ankylosing Spondylitis Functional Index (BASFI) assessed functional difficulties. Inflammatory markers and patient data were collected, and univariate/multivariate logistic regression analyses were used to explore influencing factors of ASAS-HI.
The mean ASAS-HI score was 3.52 ± 3.12. ASAS-HI was positively correlated with BASDAI ( = 0.478, < 0.001), ASDAS-CRP ( = 0.406, < 0.001), BASFI ( = 0.338, < 0.002), and BAS-G ( = 0.335, < 0.002). Patients with ASDAS-ES ≥ 2.1, ASDAS-CRP ≥ 2.1, and spinal tenderness had significantly higher ASAS-HI scores than others ( < 0.001). Spinal tenderness and radiographic grading were identified as key influencing factors.
ASAS-HI is significantly impacted by disease activity and functional limitations. Early assessment of ASAS-HI is crucial for optimizing disease management in AS patients.
本研究旨在评估潮汕地区强直性脊柱炎（AS）患者的健康相关生活质量（HRQoL），并确定影响强直性脊柱炎病情活动度评分系统健康指数（ASAS-HI）的因素，以加强AS的综合治疗策略。
对汕头大学医学院第一附属医院风湿科门诊的82例AS患者进行ASAS-HI调查。巴斯强直性脊柱炎整体评分（BAS-G）评估整体健康状况，强直性脊柱炎生活质量问卷（AS-QOL）评估生活质量，巴斯强直性脊柱炎疾病活动指数（BASDAI）测量疾病活动度，巴斯强直性脊柱炎功能指数（BASFI）评估功能障碍。收集炎症标志物和患者数据，并采用单因素/多因素逻辑回归分析探讨ASAS-HI的影响因素。
ASAS-HI平均得分为3.52±3.12。ASAS-HI与BASDAI（r = 0.478，P < 0.001）、ASDAS-CRP（r = 0.406，P < 0.001）、BASFI（r = 0.338，P < 0.002）和BAS-G（r = 0.335，P < 0.002）呈正相关。ASDAS-ES≥2.1、ASDAS-CRP≥2.1以及有脊柱压痛的患者ASAS-HI得分显著高于其他患者（P < 0.001）。脊柱压痛和影像学分级被确定为关键影响因素。
ASAS-HI受疾病活动度和功能受限的显著影响。早期评估ASAS-HI对于优化AS患者的疾病管理至关重要。
