Shoenhard Hannah, Sehgal Amita
Department of Biology, Bryn Mawr College, Bryn Mawr, PA 19010, USA; Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Trends Neurosci. 2025 Feb;48(2):93-95. doi: 10.1016/j.tins.2025.01.001. Epub 2025 Jan 22.
Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al. revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Drosophila melanogaster. This mechanism coordinates just-in-time glial energy delivery in response to dynamic neuronal needs.
记忆巩固需要迅速为神经元提供能量。在最近的一项研究中，弗朗塞斯等人揭示了一种信号，通过该信号，神经元在黑腹果蝇形成记忆的过程中指挥神经胶质细胞限制脂肪酸合成，转而促进代谢物输出。这一机制能根据神经元的动态需求协调神经胶质细胞及时提供能量。
