Jung Somin, Lee Han-Gyul, Kwon Seungwon, Cho Seung-Yeon, Park Seong-Uk, Jung Woo-Sang, Moon Sang-Kwan, Park Jung-Mi, Ko Chang-Nam
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Cardiology and Neurology, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, Republic of Korea.
Heliyon. 2024 Dec 25;11(1):e41455. doi: 10.1016/j.heliyon.2024.e41455. eCollection 2025 Jan 15.
Guillain-Barré syndrome (GBS) is a rapid-onset disease caused by the immune system damaging the peripheral nervous system. Since most standardized treatments for GBS focus on acute phase treatment, there are limitations to the rehabilitation and management of general conditions. In East Asian countries, herbal medicine has been used to treat GBS and aid rehabilitation. Therefore, herbal medicine is considered a complementary treatment for GBS. Hence, the present study was conducted to investigate the clinical evidence of herbal medicine treatment for GBS and to provide a research strategy for the future.
PubMed, Embase, Cochrane, CNKI, CiNii, and Science ON were searched from inception to December 4, 2024. Randomized controlled trials (RCTs) comparing conventional Western medicine (CWM) combined with herbal medicine (treatment group) and only CWM (control group), to evaluate the effects of herbal medicine combined with CWM as a treatment for GBS were included. All bibliographic data from the collected studies were summarized in Endnote X9 (Clarivate Analytics). The meta-analysis was conducted using Review Manager (Revman) 5.4.1. software. Effectiveness was assessed by Total Effective Rate (TER), Modified Barthel Index (mBI) score and Manual Muscle Testing (MMT) score. Safety was evaluated as the occurrence of a significant adverse events (AEs).
Ten RCTs that comprised 764 participants were included. Based on the meta-analysis, TER was found to significantly improve in the treatment group compared with the control group (risk ratios: 1.14, 95 % confidence interval: 1.09 to 1.20, p < 0.00001). The mBI score and MMT score of upper limb and lower limb also significantly improved in the treatment group compared with the control group. No significant AEs were reported in any included study.
The results of this study suggest that the combination of CWM and herbal medicine may be a better and safer method of physical function recovery and rehabilitation in patients with GBS. Further qualified studies are required to establish this hypothesis.
吉兰 - 巴雷综合征（GBS）是一种免疫系统损害周围神经系统导致的急性发病疾病。由于大多数GBS的标准化治疗集中在急性期治疗，因此在一般状况的康复和管理方面存在局限性。在东亚国家，草药已被用于治疗GBS并辅助康复。因此，草药被认为是GBS的一种补充治疗方法。因此，本研究旨在调查草药治疗GBS的临床证据，并为未来提供研究策略。
检索了从创刊至2024年12月4日的PubMed、Embase、Cochrane、中国知网（CNKI）、CiNii和Science ON。纳入比较常规西药（CWM）联合草药（治疗组）与仅使用CWM（对照组），以评估草药联合CWM作为GBS治疗效果的随机对照试验（RCT）。收集研究的所有文献数据在Endnote X9（科睿唯安）中进行总结。使用Review Manager（Revman）5.4.1软件进行荟萃分析。通过总有效率（TER）、改良巴氏指数（mBI）评分和徒手肌力测试（MMT）评分评估有效性。将严重不良事件（AE）的发生情况评估为安全性。
纳入了10项包含764名参与者的RCT。基于荟萃分析，发现治疗组的TER与对照组相比有显著改善（风险比：1.14，95%置信区间：1.09至1.20，p < 0.00001）。与对照组相比，治疗组上肢和下肢的mBI评分和MMT评分也有显著改善。在任何纳入研究中均未报告显著的AE。
本研究结果表明，CWM与草药联合使用可能是GBS患者身体功能恢复和康复的更好、更安全的方法。需要进一步的高质量研究来证实这一假设。
