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Advantages and challenges of polymer-lipid hybrid nanoparticles for the delivery of biotech drugs.

作者信息

Ottonelli Ilaria, Baraldi Cecilia, Ruozi Barbara, Vandelli Maria Angela, Tosi Giovanni, Duskey Jason T

机构信息

NanotechLab, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

出版信息

Nanomedicine (Lond). 2025 Apr;20(7):641-643. doi: 10.1080/17435889.2025.2457930. Epub 2025 Jan 24.

DOI:10.1080/17435889.2025.2457930
PMID:39851097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11970755/
Abstract
摘要

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本文引用的文献

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Polymer-lipid hybrid nanomedicines to deliver siRNA in and against glioblastoma cells.聚合物-脂质杂化纳米药物递送至胶质母细胞瘤细胞内并对抗胶质母细胞瘤细胞。
Int J Pharm. 2024 Apr 10;654:123994. doi: 10.1016/j.ijpharm.2024.123994. Epub 2024 Mar 12.
2
Tunable rigidity of PLGA shell-lipid core nanoparticles for enhanced pulmonary siRNA delivery in 2D and 3D lung cancer cell models.用于在二维和三维肺癌细胞模型中增强肺部小干扰RNA递送的聚乳酸-羟基乙酸共聚物壳-脂质核纳米颗粒的可调刚性
J Control Release. 2024 Feb;366:746-760. doi: 10.1016/j.jconrel.2024.01.029. Epub 2024 Jan 20.
3
siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy.靶向骨髓中E-选择素和亲环素A的siRNA脂质-聚合物纳米颗粒用于联合治疗多发性骨髓瘤
Cell Mol Bioeng. 2023 Sep 14;16(4):383-392. doi: 10.1007/s12195-023-00774-y. eCollection 2023 Aug.
4
Lipid-Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery.脂质-聚合物杂化纳米系统：用于先进治疗递送的合理融合。
J Funct Biomater. 2023 Aug 23;14(9):437. doi: 10.3390/jfb14090437.
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Shaping the "hot" immunogenic tumor microenvironment by nanoparticles co-delivering oncolytic peptide and TGF-β1 siRNA for boosting checkpoint blockade therapy.通过共递送溶瘤肽和TGF-β1小干扰RNA的纳米颗粒塑造“热”免疫原性肿瘤微环境以增强检查点阻断疗法
Bioeng Transl Med. 2022 Aug 11;8(5):e10392. doi: 10.1002/btm2.10392. eCollection 2023 Sep.
6
Solid Lipid-Polymer Hybrid Nanoplatform for Topical Delivery of siRNA: In Vitro Biological Activity and Permeation Studies.用于siRNA局部递送的固体脂质-聚合物杂化纳米平台：体外生物学活性和渗透研究
J Funct Biomater. 2023 Jul 17;14(7):374. doi: 10.3390/jfb14070374.
7
Synthesis of nanoparticles via microfluidic devices and integrated applications.微流控芯片法制备纳米粒子及其集成应用
Mikrochim Acta. 2023 Jun 10;190(7):256. doi: 10.1007/s00604-023-05838-4.
8
Microfluidic Technology for the Production of Hybrid Nanomedicines.用于生产混合纳米药物的微流控技术
Pharmaceutics. 2021 Sep 17;13(9):1495. doi: 10.3390/pharmaceutics13091495.
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Bioeng Transl Med. 2021 Aug 13;6(3):e10246. doi: 10.1002/btm2.10246. eCollection 2021 Sep.
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