Jang Huisoo, Jeon Junhyeon, Shin Mingyeong, Kang Geonha, Ryu Hyunil, Kim Sun Min, Jeon Tae-Joon
Industrial Science and Technology Research Institute, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.
Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.
Gels. 2025 Jan 15;11(1):66. doi: 10.3390/gels11010066.
Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. In particular, polydiacetylene (PDA) is gaining attention as an ideal material for label-free colorimetric biosensor development due to its unique color-changing properties in response to external stimuli. PDA forms through the self-assembly of diacetylene monomers, with color change occurring as its conjugated backbone twists in response to stimuli such as temperature, pH, and chemical interactions. This color change enables the detection of biomarkers, metal ions, and toxic compounds. Moreover, the combination of PDA with polymeric structures including hydrogels further enhances the sensitivity and structural stability of PDA-based biosensors, making them reliable and effective in complex biological and environmental conditions. This review comprehensively examines recent research trends and applications of PDA-polymeric structure hybrid biosensors, while discussing future directions and potential advancements in this field.
生物传感器将物理换能器与生物识别元件相结合，由于包括医学诊断、环境监测和食品安全在内的多个领域对快速诊断技术的兴趣日益浓厚，因此取得了显著进展。特别是，聚二乙炔（PDA）因其在响应外部刺激时具有独特的变色特性，作为无标记比色生物传感器开发的理想材料而受到关注。PDA通过二乙炔单体的自组装形成，随着其共轭主链响应温度、pH值和化学相互作用等刺激而扭曲，颜色发生变化。这种颜色变化能够检测生物标志物、金属离子和有毒化合物。此外，PDA与包括水凝胶在内的聚合物结构相结合，进一步提高了基于PDA的生物传感器的灵敏度和结构稳定性，使其在复杂的生物和环境条件下可靠且有效。本文综述全面审视了PDA-聚合物结构混合生物传感器的最新研究趋势和应用，同时讨论了该领域的未来方向和潜在进展。
