Fang Jianxiao, Jia Yunting, Liao Zelong, Qi Bairui, Huang Tao
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Materials Science and Engineering, Central South University, Changsha 410004, China.
Biosensors (Basel). 2024 Dec 26;15(1):5. doi: 10.3390/bios15010005.
The early monitoring of cardiovascular biomarkers is essential for the prevention and management of some cardiovascular diseases. Here, we present a novel, compact, and highly integrated skin electrode as a mechanical-electrochemical dual-model E-skin, designed for the real-time monitoring of heart rate and sweat ion concentration, two critical parameters for assessing cardiovascular health. As a pressure sensor, this E-skin is suitable for accurate heart rate monitoring, as it exhibits high sensitivity (25.2 pF·kPa), a low detection limit of 6 Pa, and a rapid response time of ~20 ms, which is attributed to the iontronic sensing interface between the skin and the electrode. Additionally, the electrode functions as a potassium ion-selective electrode based on chemical doping, achieving an enhanced response of 11 mV·mM. A test based on the real-time monitoring of a subject riding an indoor bike demonstrated the device's capability to monitor heart rate and sweat potassium ion levels reliably and accurately. This advancement in wearable technology offers significant potential for enhancing patient care based on the early detection and proactive management of cardiovascular conditions.
心血管生物标志物的早期监测对于某些心血管疾病的预防和管理至关重要。在此，我们展示了一种新型、紧凑且高度集成的皮肤电极，作为一种机械 - 电化学双模式电子皮肤，旨在实时监测心率和汗液离子浓度，这两个是评估心血管健康的关键参数。作为压力传感器，这种电子皮肤适用于精确的心率监测，因为它具有高灵敏度（25.2 pF·kPa）、6 Pa的低检测限和约20 ms的快速响应时间，这归因于皮肤与电极之间的离子电子传感界面。此外，该电极基于化学掺杂用作钾离子选择性电极，实现了11 mV·mM的增强响应。一项基于对室内骑自行车受试者进行实时监测的测试表明，该设备能够可靠且准确地监测心率和汗液钾离子水平。可穿戴技术的这一进展为基于心血管疾病的早期检测和主动管理来加强患者护理提供了巨大潜力。
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