Melebari Sami, Hafiz Abdul, Natto Hatim A, Elamin Mohamed Osman, Jalal Naif A, Hakim Ashwaq, Rushan Safiah, Fallatah Othman, Alzabeedi Kamal, Malibari Feras, Mashat Hutaf, Alsaadi Aisha, Alhakam Amani, Hadidi Anoud, Alkhaldi Ghazi Saad, Alkhyami Ahmed, Alqarni Ali, Alzahrani Abdulaziz, Alghamdi Mohammed, Siddiqi Abdullah, Alasmari Abdullah, Bakri Rowaida, Alqahtani Saleh, Al-Bajaly Juman M, Khogeer Asim
Department of Molecular Biology, The Regional Laboratory, Ministry of Health, Makkah 21955, Saudi Arabia.
Department of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Trop Med Infect Dis. 2025 Jan 20;10(1):27. doi: 10.3390/tropicalmed10010027.
Dengue fever is caused by four common serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). Patients infected with one serotype may develop lifelong serotype-specific protective immunity. However, they remain susceptible to reinfection with the other serotypes, often increasing the risk of severe forms of dengue. This cross-sectional study investigates the prevalence of the four dengue serotypes in patients who presented with dengue fever at Makkah hospitals between April 2023 and May 2024. Data were collected from the medical records of the Regional Laboratory in Makkah, Saudi Arabia. The 238 positive dengue samples included 185 samples (77.73%) from male patients. The average age of the patients was 37.65 years (SD = 15.05). Dengue type 2 was the most common serotype, followed by type 1, type 3, and type 4. Most of the dengue patients were Saudi nationals, followed by Egyptians. There were 11 dengue-positive samples that were not diagnosed with any of the four dengue serotypes. Since Makkah receives numerous international travelers, these samples might contain novel dengue serotypes circulating in different parts of the world. This study underscores the need for the continuous monitoring of dengue serotypes to predict potential outbreaks and mitigate the risk of severe dengue in susceptible populations.
登革热由四种常见的登革病毒血清型（DENV-1、DENV-2、DENV-3和DENV-4）引起。感染一种血清型的患者可能会产生终身的血清型特异性保护性免疫。然而，他们仍然易受其他血清型的再次感染，这往往会增加患严重登革热的风险。这项横断面研究调查了2023年4月至2024年5月期间在麦加医院出现登革热症状的患者中四种登革热血清型的流行情况。数据从沙特阿拉伯麦加地区实验室的病历中收集。238份登革热阳性样本中，有185份（77.73%）来自男性患者。患者的平均年龄为37.65岁（标准差 = 15.05）。登革热2型是最常见的血清型，其次是1型、3型和4型。大多数登革热患者是沙特公民，其次是埃及人。有11份登革热阳性样本未被诊断出感染四种登革热血清型中的任何一种。由于麦加接待大量国际旅行者，这些样本可能包含在世界不同地区传播的新型登革热血清型。这项研究强调了持续监测登革热血清型以预测潜在疫情并降低易感人群中严重登革热风险的必要性。
