Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China.

Influenza and pneumococcal vaccinations play a crucial role in disease prevention among older adults and are recommended to older adults aged 60 years and over in China, but the vaccination rates are suboptimal. Behavioral spillover indicates that a change in one behavior may lead to changes in other related behaviors. Based on the Behavioral Spillover Theory, this study aimed to investigate the association between influenza vaccination history and pneumococcal vaccination intention, as well as the mediating role of negative attitudes toward general vaccination among older adults in China. A multi-center cross-sectional survey was conducted among 1031 older adults, and 658 participants (median age: 65.0 ± 9.0 years) who had not received pneumococcal vaccination were included in the analysis. Correlation analysis and path analysis were performed. A significant positive association was observed between influenza vaccination history and pneumococcal vaccination intention (r = 0.167, < 0.001). In contrast, negative attitudes toward general vaccination, including mistrust of vaccine benefits (r = -0.253, < 0.001), worries about unforeseen future effects (r = -0.180, < 0.001), concerns about commercial profiteering (r = -0.360, < 0.001), and a preference for natural immunity (r = -0.212, < 0.001) were negatively associated with pneumococcal vaccination intention. Negative attitudes toward general vaccination mediated the association between influenza vaccination history and pneumococcal vaccination intention (total indirect effect = 0.119, < 0.001, effect size = 50.0%). These findings demonstrated that influenza vaccination history may reduce negative attitudes toward general vaccination, which may further increase pneumococcal vaccination intention, indicating spillover effects of influenza vaccination history. To promote vaccination behavior among older adults, addressing negative attitudes toward general vaccination is crucial.