Willshaw H E, Eastmond C J
Trans Ophthalmol Soc U K (1962). 1979 Apr;99(1):160-2.
As part of a larger study undertaken to determine whether the presence of faecal Klebsiella aerogenes was significantly associated with the clinical activity of ankylosing spondylitis, thirteen patients with ankylosing spondylitis and acute non-granulomatous anterior uveitis (ANGAU) were examined. The faeces of eleven of these thirteen patients were found to contain Klebsiella aerogenes. This association shows a statistical significance of P less than 0.01, and suggests that Klebsiella aerogenes may have an aetiological role in the development of anterior uveitis in HLA B27 positive patients. The possible mechanism of this association and its potential clinical significance are discussed.
作为一项更大规模研究的一部分，该研究旨在确定粪便中产气克雷伯菌的存在是否与强直性脊柱炎的临床活动显著相关，对13例患有强直性脊柱炎和急性非肉芽肿性前葡萄膜炎（ANGAU）的患者进行了检查。这13例患者中有11例的粪便被发现含有产气克雷伯菌。这种关联显示出统计学显著性，P值小于0.01，并表明产气克雷伯菌可能在HLA B27阳性患者前葡萄膜炎的发病中具有病因学作用。讨论了这种关联的可能机制及其潜在的临床意义。
