强直性脊柱炎患者与对照组中粪便产气克雷伯菌的频率与疾病个体特征的关系。
Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease.
作者信息
Eastmond C J, Willshaw H E, Burgess S E, Shinebaum R, Cooke E M, Wright V
出版信息
Ann Rheum Dis. 1980 Apr;39(2):118-23. doi: 10.1136/ard.39.2.118.
A study of 59 patients with definite ankylosing spondylitis and 41 comparable hospital outpatients with fractures has been undertaken to determine if the presence of faecal Klebsiella aerogenes is related to clinical activity of the spinal disease and its extraspinal features. The frequencies of fecal K. aerogenes were similar in both patients and controls and were not significantly related to spinal disease activity. Careful inquiry about antibiotic treatment, dietary habits, and hospitalisation did not significantly influence the results. A significant association was found between the presence of faecal K. aerogenes and both acute non-granulomatous anterior uveitis (P less than 0.01) and peripheral synovitis in HLA B27 positive patients (P less than 0.05). These results suggest that K. aerogenes may have an aetiological role in the development of non-granulomatous anterior uveitis and peripheral arthritis in patients with ankylosing spondylitis but do not lend support to this organism having such a role in the spinal disease itself.
一项针对59例确诊强直性脊柱炎患者和41例因骨折住院的对照门诊患者的研究已经展开，以确定粪便中产气克雷伯菌的存在是否与脊柱疾病的临床活动及其脊柱外特征有关。患者和对照组粪便中产气克雷伯菌的频率相似，且与脊柱疾病活动无显著相关性。对抗生素治疗、饮食习惯和住院情况的详细询问并未显著影响结果。在粪便中产气克雷伯菌的存在与急性非肉芽肿性前葡萄膜炎（P<0.01）以及HLA B27阳性患者的外周滑膜炎（P<0.05）之间均发现了显著关联。这些结果表明，产气克雷伯菌可能在强直性脊柱炎患者非肉芽肿性前葡萄膜炎和外周关节炎的发生中具有病因学作用，但并不支持该菌在脊柱疾病本身中发挥此类作用。
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