Eastmond C J, Calguner M, Shinebaum R, Cooke E M, Wright V
Ann Rheum Dis. 1982 Feb;41(1):15-20. doi: 10.1136/ard.41.1.15.
An 8-month sequential study at 4-weekly intervals of faecal Klebsiella aerogenes and clinical activity of ankylosing spondylitis is described. Similar frequencies of faecal K. aerogenes were found in the 44 patients and 36 healthy controls studied. Eighteen patients on 19 occasions had K. aerogenes cultured from their faeces, when the preceding specimen had been negative. Six (31.6%) of these occasions were associated with a deterioration in clinical state compared with a similar deterioration associated with only 17 (9.8%) of the remaining 174 faecal culture sequences (p less than 0.02). These results suggest that clinical deterioration in ankylosing spondylitis may be associated with the acquisition of faecal K. aerogenes.
本文描述了一项为期8个月、每隔4周进行一次的研究,该研究对产气克雷伯菌在粪便中的情况以及强直性脊柱炎的临床活动进行了观察。在研究的44例患者和36例健康对照中,发现粪便中产气克雷伯菌的频率相似。18例患者在19次粪便培养中,前一次标本为阴性时此次培养出产气克雷伯菌。与其余174次粪便培养序列中仅有17次(9.8%)出现类似恶化情况相比,这些情况中有6次(31.6%)与临床状态恶化相关(p<0.02)。这些结果表明,强直性脊柱炎的临床恶化可能与粪便中产气克雷伯菌的获得有关。