Lu Ronghua, Zhou Honghua, Yuan Jian, Ding Zifan
Department of Gastroenterology, Affiliated Haimen Hospital of Xinglin College, Nantong University, Nantong, Jiangsu Province, China.
Department of Gastroenterology, Tianchang People's Hospital, Chuzhou, Anhui Province, China.
Medicine (Baltimore). 2025 Jul 4;104(27):e43221. doi: 10.1097/MD.0000000000043221.
Anxiety and depression are mental disorders that are prevalent worldwide. Previous studies have shown that it is related to the gut microbiota. The microbiota-gut-brain axis (MGB axis) is a bidirectional signaling pathway that links the gut and central nervous systems. It plays a pivotal role in the development of psychiatric and gastrointestinal disorders, with interactions occurring via the neural, metabolic, immune, and endocrine pathways. This study aimed to reveal the research trends in the MGB axis and anxiety or depression.
Documents were retrieved from the Web of Science Core Collection with search terms for the microbiota-brain-gut axis and anxiety or depression. CiteSpace and VOSviewer are bibliometric tools used for co-citation analysis, co-occurrence analysis, collaborative network analysis, and keyword citation burst discovery.
A total of 1816 published articles were identified, indicating a yearly upward trend. China emerged as the leading contributor, accounting for 497 publications (27.37%). Notably, Nutrients published the most articles, amounting to 77 (4.24%). Regarding authors and institutions, Cryan JF emerged as the frontrunner with remarkable 115 publications, while University College Cork topped the list with 138 articles (7.60%). Keyword analysis highlighted probiotics and inflammation as prominent areas of research, while also revealing the involvement of esteemed scholars in studying the MGB axis and anxiety or depression.
These findings provide valuable insights into the current study and a future orientation in the field of the MGB axis and anxiety or depression. This information can assist researchers in selecting appropriate journals or collaborators and furthering their studies on the potential mechanisms of anxiety or depression, including their etiology, therapy, prevention, and prognosis.
焦虑和抑郁是全球普遍存在的精神障碍。先前的研究表明，它们与肠道微生物群有关。微生物-肠道-脑轴（MGB轴）是一条双向信号通路，连接肠道和中枢神经系统。它在精神疾病和胃肠道疾病的发展中起关键作用，通过神经、代谢、免疫和内分泌途径发生相互作用。本研究旨在揭示MGB轴与焦虑或抑郁的研究趋势。
从科学网核心合集检索文献，搜索词为微生物-脑-肠轴和焦虑或抑郁。CiteSpace和VOSviewer是用于共被引分析、共现分析、合作网络分析和关键词引用爆发发现的文献计量工具。
共识别出1816篇已发表文章，呈逐年上升趋势。中国成为主要贡献者，占497篇出版物（27.37%）。值得注意的是，《营养素》发表的文章最多，达77篇（4.24%）。关于作者和机构，克莱恩·JF以115篇显著的出版物领先，而科克大学学院以138篇文章（7.60%）位居榜首列表。关键词分析突出了益生菌和炎症是突出的研究领域，同时也揭示了知名学者参与研究MGB轴与焦虑或抑郁。
这些发现为MGB轴与焦虑或抑郁领域的当前研究和未来方向提供了有价值的见解。这些信息可帮助研究人员选择合适的期刊或合作者，并进一步研究焦虑或抑郁的潜在机制，包括其病因、治疗、预防和预后。
