从一名64岁患前列腺癌的中国汉族男性身上获得诱导多能干细胞FDZSi003-A。
Derivation of induced pluripotent stem cell FDZSi003-A from a 64-year-old Chinese Han with Prostate cancer.
作者信息
Xie Xue-Feng, Lu Xue-Qiang, Chen Zhuo, Cui Hao-Yu, Wang Xun, Zhu Zhe, Zhang Bei, Hou Chuan-Sheng
机构信息
Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
Shanghai Public Health Clinical Center Affiliated to Fudan University, 2901 Caolang Road, Jinshan, Shanghai 201508, China.
出版信息
Stem Cell Res. 2025 Mar;83:103658. doi: 10.1016/j.scr.2025.103658. Epub 2025 Jan 13.
Prostate cancer (PCa) is the most common malignant tumor of the male reproductive system. In this study, we establish an induced pluripotent stem cell (iPSC) line from a male diagnosed with PC. of This iPSCs line was generated from the peripheral blood mononuclear cells (PBMCs) using a non-integrated Sendai virus. It shows a normal karyotype, and has abilities of expressing pluripotent markers and differentiating into three germ layers.
前列腺癌（PCa）是男性生殖系统最常见的恶性肿瘤。在本研究中，我们从一名被诊断为前列腺癌的男性患者身上建立了诱导多能干细胞（iPSC）系。该iPSC系是使用非整合型仙台病毒从外周血单个核细胞（PBMC）中产生的。它显示出正常的核型，并具有表达多能性标志物和分化为三个胚层的能力。
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