从一名67岁中国汉族前列腺癌患者身上获得诱导多能干细胞FDZSi002 - A。
Derivation of induced pluripotent stem cell FDZSi002-A from a 67-year-old Chinese Han Prostate cancer patient.
作者信息
Hou Chuan-Sheng, Zhu Zhe, Xie Xue-Feng, Lu Xue-Qiang, Chen Zhuo, Cui Hao-Yu, Wu Hao, Zhang Bei, Hou Chuan-Sheng
机构信息
Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
Shanghai Public Health Clinical Center Affiliated to Fudan University, 2901 Caolang Road, Jinshan, Shanghai 201508, China.
出版信息
Stem Cell Res. 2025 Mar;83:103659. doi: 10.1016/j.scr.2025.103659. Epub 2025 Jan 7.
Prostate cancer (PCa) is the most common malignant tumor of the male reproductive system. In this study, we generated an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 67-year-old male patient and diagnosed with PC. The established iPSCs were confirmed by flow cytometry and immunofluorescence. Furthermore, the iPSC line has a normal chromosomal karyotype and has the potential of spontaneous differentiation into three germ layers in vitro. The iPSC line will be a useful tool for investigating the pathogenesis mechanisms of PCa.
前列腺癌（PCa）是男性生殖系统最常见的恶性肿瘤。在本研究中，我们从一名67岁被诊断为前列腺癌的男性患者的外周血单个核细胞（PBMC）中生成了诱导多能干细胞（iPSC）系。通过流式细胞术和免疫荧光对所建立的iPSC进行了鉴定。此外，该iPSC系具有正常的染色体核型，并且在体外具有自发分化为三个胚层的潜力。该iPSC系将成为研究前列腺癌发病机制的有用工具。
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